Entrepreneurial behaviour and the development of entrepreneurial ecosystems under uncertainty: essays on regenerative medicine venturing at the university-industry boundary
- Publisher: The University of Edinburgh
entrepreneurial behaviour | technology transfer | coping strategies | regenerative medicine | venturing
Entrepreneurial ecosystems are an important economic consideration but remain an
understudied phenomenon. In particular, research emphasising the role of the
entrepreneur within entrepreneurial ecosystems is scant. Entrepreneurial universities,
particularly the commercialisation activities by academic entrepreneurs, contribute to
both the emergence and development of entrepreneurial ecosystems at the university-industry
(U-I) boundary. Yet, an understanding of the links between university
characteristics and micro-level cognition on entrepreneurial ecosystems remains
limited. Furthermore, it is not clear how the dynamics of entrepreneurial ecosystems
differ across different national geographies.
Venture development at the U-I boundary is difficult and uncertain. Entrepreneurs
must make decisions under intense ambiguity and make sense of the highly uncertain
situation. Nowhere is this more evident than in knowledge and technology-intensive
sectors, where venturing relies on entrepreneurial coping responses to uncertainty.
However, little is known about how entrepreneurs cope with uncertainty, especially
when uncertainty is irreducible.
To progress understanding of entrepreneurial behaviour amidst uncertainty, and the
emergence and development of entrepreneurial ecosystems at the U-I boundary, this
PhD thesis investigates venturing in the field of regenerative medicine (regenmed).
This is a particularly suited study context since regenmed commercialisation
activities, which are driven by university-based stem cell research, are highly
uncertain and the industry is still in a formative stage.
This PhD thesis explores entrepreneurial behaviour amidst uncertainty and the
development of entrepreneurial ecosystems at the U-I boundary. The thesis
comprises of three empirical studies (essays) that can be read independently,
however, together the essays provide an enhanced understanding of entrepreneurial
behaviour and the development of entrepreneurial ecosystems at the U-I boundary.
Essay 1 reveals how ecosystem participants make sense of venturing processes in a
highly uncertain, technology-intensive field. It highlights the development of coping
strategies during the sensemaking process, and illustrates an association between
university entrepreneurial culture and coping strategies. A model of sensemaking
process under uncertainty is presented and a typology of sensemaking types in
uncertain ecosystems is proposed.
Essay 2 is a cross-national study of entrepreneurial ecosystems in Edinburgh (UK)
and Madison (USA). The study investigates the development of entrepreneurial
ecosystems around two research-intensive universities, which have a long history in
stem cell innovation. The essay highlights the effects of cultural artefacts on microlevel
behaviours. The influence of behaviour and cognition on the development of
entrepreneurial ecosystems is modelled. This reveals different development paths for
Essay 3 explores the emergence and development of entrepreneurial ecosystems, and
considers how these help drive technology-based economies. More specifically, the
study explores technology transfer and contextual factors across three regenmed
ecosystems (Edinburgh, Madison, and Moscow) to reveal the emergence of
entrepreneurial ecosystems at the U-I boundary. Findings show that ecosystem and
venture characteristics emerge from institutional characteristics, micro-level
cognition and regional context. Additionally, university culture and entrepreneurial
coping strategies generate a typology for spinouts within the ecosystem.
Collectively, these three essays reveal novel phenomena explaining how ecosystem
actors make sense of uncertainty and how this influences the emergence of
entrepreneurial ecosystems at the U-I boundary. Additionally, they reveal the
importance of context in the venturing process and in entrepreneurial ecosystem
dynamics. This provides important contributions to theories of entrepreneurial
behaviour, entrepreneurial ecosystems and technology transfer. These scholarly
contributions impart important practical implications.
views in local repository
downloads in local repository
The information is available from the following content providers: