publication . Doctoral thesis . 2007

Experimental and Clinical Studies of Oxidative Stress in Pre-Eclampsia

Nash, Peppi;
Open Access English
  • Published: 01 Jan 2007
  • Publisher: Uppsala universitet, Institutionen för medicinsk cellbiologi
  • Country: Sweden
Abstract
Impaired placentation and oxidative stress are proposed to play major roles in the pathogenesis of pre-eclampsia (PE). It has recently been pointed out that PE might be more than one disease and may have several different pathogeneses. This thesis describes a new animal model for PE and examines the role of oxidative stress in early respective late onset PE. The effects of Suramin injections on day 10 and 11 of pregnancy were investigated in normal and diabetic rats of two strains (U and H), with or without additional vitamin E treatment. Suramin caused placental dysfunction in both rat strains: foetal growth restriction, increased resorption rate, reduced place...
Subjects
free text keywords: Obstetrics and gynaecology, Pre-eclampsia, Oxidative stress, Diabetes, Placenta, Rat, Antioxidants, Suramin, Vitamin E, Vitamin C, PAI-1, PAI-2, Obstetrik och kvinnosjukdomar
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