publication . Doctoral thesis . 2016

Nitric oxide : An ally in extracorporeal circulation?

Melki, Vilyam;
Open Access English
  • Published: 01 Jan 2016
  • Publisher: Uppsala universitet, Thoraxkirurgi
  • Country: Sweden
Many complications associated with heart surgery are due to the negative effects of extracorporeal circulation (ECC). Some of these complications may be attributed to ECC-induced activation of inflammation and coagulation pathways. The inflammatory reaction may be caused by the interaction of blood components with air and the artificial surfaces of the ECC, from substances produced due to ischaemia-reperfusion injury of the heart and lungs, and from increased release of endotoxin from ischemic intestines. Staphylococcus aureus (S. aureus) infections are the leading cause of respiratory, skin and soft tissue, and bloodstream infections. Nitric oxide (NO) is a gas...
free text keywords: Simulated extracorporeal circulation, Inflammation, Nitric oxide, Leukocyte activation, Staphylococcus aureus, Glyceryl trinitrate, Postoperative infection
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