Cationization increases brain distribution of an amyloid-beta protofibril selective F(ab')2 fragment

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Syvänen, Stina ; Edén, Desireé ; Sehlin, Dag (2017)
  • Publisher: Uppsala universitet, Geriatrik
  • Related identifiers: doi: 10.1016/j.bbrc.2017.09.065
  • Subject: Cationization | Adsorptive-mediated transcytosis | Alzheimer's disease | Amyloid-beta protofibrils | Molecular imaging | Blood-brain barrier | Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) | Medicinsk bioteknologi (med inriktning mot cellbiologi (inklusive stamcellsbiologi), molekylärbiologi, mikrobiologi, biokemi eller biofarmaci)

Antibodies and fragments thereof are, because of high selectivity for their targets, considered as potential therapeutics and biomarkers for several neurological disorders. However, due to their large molecular size, antibodies/fragments do not easily penetrate into the... View more
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