publication . Doctoral thesis . 2017

United in Diversity : A Physiological and Molecular Characterization of Subpopulations in the Basal Ganglia Circuitry

Viereckel, Thomas;
Open Access English
  • Published: 01 Jan 2017
  • Publisher: Uppsala universitet, Institutionen för neurovetenskap
  • Country: Norway
Abstract
The Basal Ganglia consist of a number of different nuclei that form a diverse circuitry of GABAergic, dopaminergic and glutamatergic neurons. This complex network is further organized in subcircuits that govern limbic and motor functions in humans and other vertebrates. Due to the interconnection of the individual structures, dysfunction in one area or cell population can affect the entire network, leading to synaptic and molecular alterations in the circuitry as a whole. The studies in this doctoral thesis aimed at characterizing restricted subpopulations of neurons in the Basal Ganglia circuitry and their importance in the wider function of the network. To thi...
Subjects
Medical Subject Headings: nervous system
free text keywords: Glutamate, Optogenetics, Amperometry, Histology, Midbrain, Subthalamic Nucleus, Parkinson's disease, Ventral Tegmental Area, Substantia Nigra, Co-release, Neurosciences, Neurovetenskaper, Physiology, Fysiologi, Medical Laboratory and Measurements Technologies, Medicinsk laboratorie- och mätteknik
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