publication . Bachelor thesis . 2005

Integrin Signalling

Schelfaut, Roselien;
Open Access English
  • Published: 01 Jan 2005
  • Publisher: Uppsala universitet, Institutionen för medicinsk biokemi och mikrobiologi
  • Country: Norway
Abstract
Integrins are receptors presented on most cells. By binding ligand they can generate signalling pathways inside the cell. Those pathways are a linkage to proteins in the cytosol. It is known that tumor cells can survive and proliferate in the absence of a solid support while normal cells need to be bound to ligand. To understand why tumour cells act that way, we first have to know how ligand-binding to integrins affect the cell. This research field includes studies on activation of proteins by integrins and the following protein-protein interactions. The part of the research that I did, focused on the activation of PI3K by integrins and the question whether Ras ...
Subjects
free text keywords: Cell surface receptors - integrins - Ras - PI3K, Cell and molecular biology, Cell- och molekylärbiologi
Related Organizations
21 references, page 1 of 2

RESULTS AND DISCUSSION .....................................................................................30 PULL-DOWN ASSAY ............................................................................................30 5.1.1 Results .....................................................................................................................31 FACSCAN AND CELL-ATTACHMENT ..............................................................31 WOUNDASSAY ......................................................................................................34 n ) 0,8 e m

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