publication . Doctoral thesis . 2010

Reproductive and Metabolic Consequences of the Polycystic Ovarian Syndrome

Hudecova, Miriam;
Open Access English
  • Published: 01 Jan 2010
  • Publisher: Uppsala universitet, Institutionen för kvinnors och barns hälsa
  • Country: Sweden
Abstract
Polycystic ovary syndrome (PCOS) is a complex clinical condition characterized by hyperandrogenism and chronic oligo/anovulation. Infrequent ovulation and metabolic alterations in women with PCOS are associated with subfertility and probably increased miscarriage rates compared with normal fertile women. The overall risk of developing type 2 diabetes and impaired glucose tolerance (IGT) is three- to sevenfold higher in PCOS women, and the onset of glucose intolerance seems to occur at an earlier age than in healthy controls. Women with PCOS also have several risk factors for cardiovascular disease, although it is unclear whether they actually experience more car...
Subjects
Medical Subject Headings: endocrine system diseasesfemale genital diseases and pregnancy complicationsnutritional and metabolic diseases
free text keywords: polycystic ovarian syndrome, long-term follow-up, ovarian reserve, anti-Müllerian hormone, insulin sensitivity, early insuline response, impaired glucose tolerance, diabetes, endothelial function, endothelial-dependent vasodilation, Obstetrics and gynaecology, Obstetrik och gynekologi
Related Organizations
39 references, page 1 of 3

Introduction ............................................................................................. 11 Definition of PCOS ........................................................................ 11 Clinical features of PCOS .............................................................. 12 Pathophysiology of PCOS.............................................................. 12 Reproductive consequences of PCOS ............................................ 15 Ovarian reserve .............................................................................. 16 Metabolic consequences of PCOS ................................................. 17 Cardiovascular consequences of PCOS ......................................... 20 Prior long-term studies in women with PCOS ............................... 21 Asuncion M, Calvo RM, San Millan JL, Sancho J, Avila S, EscobarMorreale HF. A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain. J Clin Endocrinol Metab 2000;85:2434-8.

Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab 2004;89:2745-9. [OpenAIRE]

Diamanti-Kandarakis E, Kouli CR, Bergiele AT, Filandra FA, Tsianateli TC, Spina GG, Zapanti ED, Bartzis MI. A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile. J Clin Endocrinol Metab 1999;84:4006-11. [OpenAIRE]

Prevalence of symptoms associated with polycystic ovary syndrome. Int J Gynaecol Obstet 2008;102:39-43.

Taponen S, Martikainen H, Jarvelin MR, Laitinen J, Pouta A, Hartikainen AL, Sovio U, McCarthy MI, Franks S, Ruokonen A. Hormonal profile of women with self-reported symptoms of oligomenorrhea and/or hirsutism: Northern Finland birth cohort 1966 study. J Clin Endocrinol Metab 2003;88:141-7. [OpenAIRE]

Zawadski, J., Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. In: Dunaif A, Givens JR, Haseltine FP, Merriam GR, eds. Polycystic ovary syndrome., in Boston: Blackwell Scientific Publications. 1992. p. 377-384.

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004;81:19-25.

Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, EscobarMorreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, Witchel SF. Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. J Clin Endocrinol Metab 2006;91:4237-45. [OpenAIRE]

Fehring RJ, Schneider M, Raviele K. Variability in the phases of the menstrual cycle. J Obstet Gynecol Neonatal Nurs 2006;35:376-84. [OpenAIRE]

Ferriman D, Gallwey JD. Clinical assessment of body hair growth in women. J Clin Endocrinol Metab 1961;21:1440-7. [OpenAIRE]

Manni A, Pardridge WM, Cefalu W, Nisula BC, Bardin CW, Santner SJ, Santen RJ. Bioavailability of albumin-bound testosterone. J Clin Endocrinol Metab 1985;61:705-10.

gonadotrophins and sex steroids in premenopausal women. Clin Endocrinol (Oxf) 1994;41:473-81.

Roberts JE, Spandorfer S, Fasouliotis SJ, Kashyap S, Rosenwaks Z. Taking a basal follicle-stimulating hormone history is essential before initiating in vitro fertilization. Fertil Steril 2005;83:37-41. [OpenAIRE]

Dahlgren E, Johansson S, Lindstedt G, Knutsson F, Oden A, Janson PO, Mattson LA, Crona N, Lundberg PA. Women with polycystic ovary syndrome wedge resected in 1956 to 1965: a long-term follow-up focusing on natural history and circulating hormones. Fertil Steril 1992;57:505-13.

Robertson DM, Cahir N, Findlay JK, Burger HG, Groome N. The biological and immunological characterization of inhibin A and B forms in human follicular fluid and plasma. J Clin Endocrinol Metab 1997;82:889- 96. [OpenAIRE]

39 references, page 1 of 3
Abstract
Polycystic ovary syndrome (PCOS) is a complex clinical condition characterized by hyperandrogenism and chronic oligo/anovulation. Infrequent ovulation and metabolic alterations in women with PCOS are associated with subfertility and probably increased miscarriage rates compared with normal fertile women. The overall risk of developing type 2 diabetes and impaired glucose tolerance (IGT) is three- to sevenfold higher in PCOS women, and the onset of glucose intolerance seems to occur at an earlier age than in healthy controls. Women with PCOS also have several risk factors for cardiovascular disease, although it is unclear whether they actually experience more car...
Subjects
Medical Subject Headings: endocrine system diseasesfemale genital diseases and pregnancy complicationsnutritional and metabolic diseases
free text keywords: polycystic ovarian syndrome, long-term follow-up, ovarian reserve, anti-Müllerian hormone, insulin sensitivity, early insuline response, impaired glucose tolerance, diabetes, endothelial function, endothelial-dependent vasodilation, Obstetrics and gynaecology, Obstetrik och gynekologi
Related Organizations
39 references, page 1 of 3

Introduction ............................................................................................. 11 Definition of PCOS ........................................................................ 11 Clinical features of PCOS .............................................................. 12 Pathophysiology of PCOS.............................................................. 12 Reproductive consequences of PCOS ............................................ 15 Ovarian reserve .............................................................................. 16 Metabolic consequences of PCOS ................................................. 17 Cardiovascular consequences of PCOS ......................................... 20 Prior long-term studies in women with PCOS ............................... 21 Asuncion M, Calvo RM, San Millan JL, Sancho J, Avila S, EscobarMorreale HF. A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain. J Clin Endocrinol Metab 2000;85:2434-8.

Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab 2004;89:2745-9. [OpenAIRE]

Diamanti-Kandarakis E, Kouli CR, Bergiele AT, Filandra FA, Tsianateli TC, Spina GG, Zapanti ED, Bartzis MI. A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile. J Clin Endocrinol Metab 1999;84:4006-11. [OpenAIRE]

Prevalence of symptoms associated with polycystic ovary syndrome. Int J Gynaecol Obstet 2008;102:39-43.

Taponen S, Martikainen H, Jarvelin MR, Laitinen J, Pouta A, Hartikainen AL, Sovio U, McCarthy MI, Franks S, Ruokonen A. Hormonal profile of women with self-reported symptoms of oligomenorrhea and/or hirsutism: Northern Finland birth cohort 1966 study. J Clin Endocrinol Metab 2003;88:141-7. [OpenAIRE]

Zawadski, J., Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. In: Dunaif A, Givens JR, Haseltine FP, Merriam GR, eds. Polycystic ovary syndrome., in Boston: Blackwell Scientific Publications. 1992. p. 377-384.

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004;81:19-25.

Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, EscobarMorreale HF, Futterweit W, Janssen OE, Legro RS, Norman RJ, Taylor AE, Witchel SF. Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. J Clin Endocrinol Metab 2006;91:4237-45. [OpenAIRE]

Fehring RJ, Schneider M, Raviele K. Variability in the phases of the menstrual cycle. J Obstet Gynecol Neonatal Nurs 2006;35:376-84. [OpenAIRE]

Ferriman D, Gallwey JD. Clinical assessment of body hair growth in women. J Clin Endocrinol Metab 1961;21:1440-7. [OpenAIRE]

Manni A, Pardridge WM, Cefalu W, Nisula BC, Bardin CW, Santner SJ, Santen RJ. Bioavailability of albumin-bound testosterone. J Clin Endocrinol Metab 1985;61:705-10.

gonadotrophins and sex steroids in premenopausal women. Clin Endocrinol (Oxf) 1994;41:473-81.

Roberts JE, Spandorfer S, Fasouliotis SJ, Kashyap S, Rosenwaks Z. Taking a basal follicle-stimulating hormone history is essential before initiating in vitro fertilization. Fertil Steril 2005;83:37-41. [OpenAIRE]

Dahlgren E, Johansson S, Lindstedt G, Knutsson F, Oden A, Janson PO, Mattson LA, Crona N, Lundberg PA. Women with polycystic ovary syndrome wedge resected in 1956 to 1965: a long-term follow-up focusing on natural history and circulating hormones. Fertil Steril 1992;57:505-13.

Robertson DM, Cahir N, Findlay JK, Burger HG, Groome N. The biological and immunological characterization of inhibin A and B forms in human follicular fluid and plasma. J Clin Endocrinol Metab 1997;82:889- 96. [OpenAIRE]

39 references, page 1 of 3
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