publication . Article . 2018

Increased circulating resistin levels in early-onset breast cancer patients of normal body mass index correlate with lymph node negative involvement and longer disease free survival: a multi-center POSH cohort serum proteomics study

Cory White;
  • Published: 01 Mar 2018
Abstract
<b>Background</b><br/><p class="Para" style="box-sizing: inherit; margin-top: 0px; margin-bottom: 24px; word-break: break-word;">Early-onset breast cancer (EOBC) affects about one in 300 women aged 40 years or younger and is associated with worse outcomes than later onset breast cancer. This study explored novel serum proteins as surrogate markers of prognosis in patients with EOBC.</p><b>Methods</b><b><br/></b><p class="Para" style="box-sizing: inherit; margin-top: 0px; margin-bottom: 24px; word-break: break-word;">Serum samples from EOBC patients (stages 1–3) were analysed using agnostic high-precision quantitative proteomics. Patients received anthracycline-b...
Subjects
free text keywords: Research Article, Quantitative serum proteomics, Resistin, Insulin resistance, Glycolysis/gluconeogenesis, lymph-node involvement, Early-onset breast cancer, Cancer Research, Oncology, Progesterone receptor, Breast cancer, medicine.disease, medicine, medicine.medical_specialty, Survival analysis, business.industry, business, Internal medicine, Blood proteins, Prospective cohort study, Body mass index
47 references, page 1 of 4

Eccles, D, Gerty, S, Simmonds, P, Hammond, V, Ennis, S, Altman, DG. Steering Group. Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (POSH): study protocol. BMC Cancer. 2007; 7: 160 [OpenAIRE] [PubMed] [DOI]

Copson, E, Eccles, B, Maishman, T, Gerty, S, Stanton, L, Cutress, RI, Altman, DG, Durcan, L, Simmonds, P, Lawrence, G. Prospective observational study of breast cancer treatment outcomes for UK women aged 18-40 years at diagnosis: the POSH study. J Natl Cancer Inst. 2013; 105 (13): 978-988 [OpenAIRE] [PubMed] [DOI]

Candido Dos Reis, FJ, Wishart, GC, Dicks, EM, Greenberg, D, Rashbass, J, Schmidt, MK, van den Broek, AJ, Ellis, IO, Green, A, Rakha, E. An updated PREDICT breast cancer prognostication and treatment benefit prediction model with independent validation. Breast Cancer Res. 2017; 19 (1): 58 [OpenAIRE] [PubMed] [DOI]

Zeidan, BA, Townsend, PA, Garbis, SD, Copson, E, Cutress, RI. Clinical proteomics and breast cancer. Surgeon. 2015; 13 (5): 271-278 [OpenAIRE] [PubMed] [DOI]

5.Moulder R, Bhosale SD, Goodlett DR, Lahesmaa R. Analysis of the plasma proteome using iTRAQ and TMT-based isobaric labeling. Mass Spectrom Rev. 2017. 10.1002/mas.21550. [Epub ahead of print].

Rauniyar, N, Yates, JR. Isobaric labeling-based relative quantification in shotgun proteomics. J Proteome Res. 2014; 13 (12): 5293-5309 [OpenAIRE] [PubMed] [DOI]

Meng, R, Gormley, M, Bhat, VB, Rosenberg, A, Quong, AA. Low abundance protein enrichment for discovery of candidate plasma protein biomarkers for early detection of breast cancer. J Proteomics. 2011; 75 (2): 366-374 [OpenAIRE] [PubMed] [DOI]

Opstal-van Winden, AW, Krop, EJ, Karedal, MH, Gast, MC, Lindh, CH, Jeppsson, MC, Jonsson, BA, Grobbee, DE, Peeters, PH, Beijnen, JH. Searching for early breast cancer biomarkers by serum protein profiling of pre-diagnostic serum; a nested case-control study. BMC Cancer. 2011; 11: 381 [OpenAIRE] [PubMed] [DOI]

Garbis, SD, Roumeliotis, TI, Tyritzis, SI, Zorpas, KM, Pavlakis, K, Constantinides, CA. A novel multidimensional protein identification technology approach combining protein size exclusion prefractionation, peptide zwitterion-ion hydrophilic interaction chromatography, and nano-ultraperformance RP chromatography/nESI-MS2 for the in-depth analysis of the serum proteome and phosphoproteome: application to clinical sera derived from humans with benign prostate hyperplasia. Anal Chem. 2011; 83 (3): 708-718 [OpenAIRE] [PubMed] [DOI]

Copson, ER, Cutress, RI, Maishman, T, Eccles, BK, Gerty, S, Stanton, L, Altman, DG, Durcan, L, Wong, C, Simmonds, PD. Obesity and the outcome of young breast cancer patients in the UK: the POSH study. Ann Oncol. 2015; 26 (1): 101-112 [OpenAIRE] [PubMed] [DOI]

Johnston, HE, Carter, MJ, Cox, KL, Dunscombe, M, Manousopoulou, A, Townsend, PA, Garbis, SD, Cragg, MS. Integrated cellular and plasma proteomics of contrasting B-cell cancers reveals common, unique and systemic signatures. Mol Cell Proteomics. 2017; 16 (3): 386-406 [OpenAIRE] [PubMed] [DOI]

Al-Daghri, NM, Al-Attas, OS, Johnston, HE, Singhania, A, Alokail, MS, Alkharfy, KM, Abd-Alrahman, SH, Sabico, SL, Roumeliotis, TI, Manousopoulou-Garbis, A. Whole serum 3D LC-nESI-FTMS quantitative proteomics reveals sexual dimorphism in the milieu interieur of overweight and obese adults. J Proteome Res. 2014; 13 (11): 5094-5105 [OpenAIRE] [PubMed] [DOI]

Al-Daghri, NM, Alokail, MS, Manousopoulou, A, Heinson, A, Al-Attas, O, Al-Saleh, Y, Sabico, S, Yakout, S, Woelk, CH, Chrousos, GP. Sex-specific vitamin D effects on blood coagulation among overweight adults. Eur J Clin Invest. 2016; 46 (12): 1031-1040 [OpenAIRE] [PubMed] [DOI]

Larkin, SE, Johnston, HE, Jackson, TR, Jamieson, DG, Roumeliotis, TI, Mockridge, CI, Michael, A, Manousopoulou, A, Papachristou, EK, Brown, MD. Detection of candidate biomarkers of prostate cancer progression in serum: a depletion-free 3D LC/MS quantitative proteomics pilot study. Br J Cancer. 2016; 115 (9): 1078-1086 [OpenAIRE] [PubMed] [DOI]

Manousopoulou, A, Koutmani, Y, Karaliota, S, Woelk, CH, Manolakos, ES, Karalis, K, Garbis, SD. Hypothalamus proteomics from mouse models with obesity and anorexia reveals therapeutic targets of appetite regulation. Nutr Diabetes. 2016; 6: e204 [OpenAIRE] [PubMed] [DOI]

47 references, page 1 of 4
Abstract
<b>Background</b><br/><p class="Para" style="box-sizing: inherit; margin-top: 0px; margin-bottom: 24px; word-break: break-word;">Early-onset breast cancer (EOBC) affects about one in 300 women aged 40 years or younger and is associated with worse outcomes than later onset breast cancer. This study explored novel serum proteins as surrogate markers of prognosis in patients with EOBC.</p><b>Methods</b><b><br/></b><p class="Para" style="box-sizing: inherit; margin-top: 0px; margin-bottom: 24px; word-break: break-word;">Serum samples from EOBC patients (stages 1–3) were analysed using agnostic high-precision quantitative proteomics. Patients received anthracycline-b...
Subjects
free text keywords: Research Article, Quantitative serum proteomics, Resistin, Insulin resistance, Glycolysis/gluconeogenesis, lymph-node involvement, Early-onset breast cancer, Cancer Research, Oncology, Progesterone receptor, Breast cancer, medicine.disease, medicine, medicine.medical_specialty, Survival analysis, business.industry, business, Internal medicine, Blood proteins, Prospective cohort study, Body mass index
47 references, page 1 of 4

Eccles, D, Gerty, S, Simmonds, P, Hammond, V, Ennis, S, Altman, DG. Steering Group. Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (POSH): study protocol. BMC Cancer. 2007; 7: 160 [OpenAIRE] [PubMed] [DOI]

Copson, E, Eccles, B, Maishman, T, Gerty, S, Stanton, L, Cutress, RI, Altman, DG, Durcan, L, Simmonds, P, Lawrence, G. Prospective observational study of breast cancer treatment outcomes for UK women aged 18-40 years at diagnosis: the POSH study. J Natl Cancer Inst. 2013; 105 (13): 978-988 [OpenAIRE] [PubMed] [DOI]

Candido Dos Reis, FJ, Wishart, GC, Dicks, EM, Greenberg, D, Rashbass, J, Schmidt, MK, van den Broek, AJ, Ellis, IO, Green, A, Rakha, E. An updated PREDICT breast cancer prognostication and treatment benefit prediction model with independent validation. Breast Cancer Res. 2017; 19 (1): 58 [OpenAIRE] [PubMed] [DOI]

Zeidan, BA, Townsend, PA, Garbis, SD, Copson, E, Cutress, RI. Clinical proteomics and breast cancer. Surgeon. 2015; 13 (5): 271-278 [OpenAIRE] [PubMed] [DOI]

5.Moulder R, Bhosale SD, Goodlett DR, Lahesmaa R. Analysis of the plasma proteome using iTRAQ and TMT-based isobaric labeling. Mass Spectrom Rev. 2017. 10.1002/mas.21550. [Epub ahead of print].

Rauniyar, N, Yates, JR. Isobaric labeling-based relative quantification in shotgun proteomics. J Proteome Res. 2014; 13 (12): 5293-5309 [OpenAIRE] [PubMed] [DOI]

Meng, R, Gormley, M, Bhat, VB, Rosenberg, A, Quong, AA. Low abundance protein enrichment for discovery of candidate plasma protein biomarkers for early detection of breast cancer. J Proteomics. 2011; 75 (2): 366-374 [OpenAIRE] [PubMed] [DOI]

Opstal-van Winden, AW, Krop, EJ, Karedal, MH, Gast, MC, Lindh, CH, Jeppsson, MC, Jonsson, BA, Grobbee, DE, Peeters, PH, Beijnen, JH. Searching for early breast cancer biomarkers by serum protein profiling of pre-diagnostic serum; a nested case-control study. BMC Cancer. 2011; 11: 381 [OpenAIRE] [PubMed] [DOI]

Garbis, SD, Roumeliotis, TI, Tyritzis, SI, Zorpas, KM, Pavlakis, K, Constantinides, CA. A novel multidimensional protein identification technology approach combining protein size exclusion prefractionation, peptide zwitterion-ion hydrophilic interaction chromatography, and nano-ultraperformance RP chromatography/nESI-MS2 for the in-depth analysis of the serum proteome and phosphoproteome: application to clinical sera derived from humans with benign prostate hyperplasia. Anal Chem. 2011; 83 (3): 708-718 [OpenAIRE] [PubMed] [DOI]

Copson, ER, Cutress, RI, Maishman, T, Eccles, BK, Gerty, S, Stanton, L, Altman, DG, Durcan, L, Wong, C, Simmonds, PD. Obesity and the outcome of young breast cancer patients in the UK: the POSH study. Ann Oncol. 2015; 26 (1): 101-112 [OpenAIRE] [PubMed] [DOI]

Johnston, HE, Carter, MJ, Cox, KL, Dunscombe, M, Manousopoulou, A, Townsend, PA, Garbis, SD, Cragg, MS. Integrated cellular and plasma proteomics of contrasting B-cell cancers reveals common, unique and systemic signatures. Mol Cell Proteomics. 2017; 16 (3): 386-406 [OpenAIRE] [PubMed] [DOI]

Al-Daghri, NM, Al-Attas, OS, Johnston, HE, Singhania, A, Alokail, MS, Alkharfy, KM, Abd-Alrahman, SH, Sabico, SL, Roumeliotis, TI, Manousopoulou-Garbis, A. Whole serum 3D LC-nESI-FTMS quantitative proteomics reveals sexual dimorphism in the milieu interieur of overweight and obese adults. J Proteome Res. 2014; 13 (11): 5094-5105 [OpenAIRE] [PubMed] [DOI]

Al-Daghri, NM, Alokail, MS, Manousopoulou, A, Heinson, A, Al-Attas, O, Al-Saleh, Y, Sabico, S, Yakout, S, Woelk, CH, Chrousos, GP. Sex-specific vitamin D effects on blood coagulation among overweight adults. Eur J Clin Invest. 2016; 46 (12): 1031-1040 [OpenAIRE] [PubMed] [DOI]

Larkin, SE, Johnston, HE, Jackson, TR, Jamieson, DG, Roumeliotis, TI, Mockridge, CI, Michael, A, Manousopoulou, A, Papachristou, EK, Brown, MD. Detection of candidate biomarkers of prostate cancer progression in serum: a depletion-free 3D LC/MS quantitative proteomics pilot study. Br J Cancer. 2016; 115 (9): 1078-1086 [OpenAIRE] [PubMed] [DOI]

Manousopoulou, A, Koutmani, Y, Karaliota, S, Woelk, CH, Manolakos, ES, Karalis, K, Garbis, SD. Hypothalamus proteomics from mouse models with obesity and anorexia reveals therapeutic targets of appetite regulation. Nutr Diabetes. 2016; 6: e204 [OpenAIRE] [PubMed] [DOI]

47 references, page 1 of 4
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 2018

Increased circulating resistin levels in early-onset breast cancer patients of normal body mass index correlate with lymph node negative involvement and longer disease free survival: a multi-center POSH cohort serum proteomics study

Cory White;