Evaluation of the efficacy of ChAd63-MVA vectored vaccines expressing CS & ME-TRAP against controlled human malaria infection in malaria naïve individuals

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Hodgson, S.H. ; Ewer, K.J. ; Bliss, C.M. ; Edwards, N.J. ; Rampling, T. ; Anagnostou, N.A. ; de Barra, E. ; Havelock, T. ; Bowyer, G. ; Poulton, I.D. ; de Cassan, S. ; Illingworth, J.J. ; Douglas, A.D. ; Mange, P.B. ; Collins, K.A. ; Roberts, R. ; Gerry, S. ; Berrie, E. ; Moyle, S. ; Colloca, S. ; Cortese, R. ; Sinden, R.E. ; Gilbert, S.C. ; Bejon, P. ; Lawrie, A.M. ; Nicosia, A. ; Faust, S.N . ; Hill, A.V. (2015)

Background.?Circumsporozoite protein (CS) is the antigenic target for RTS,S, the most advanced malaria vaccine to date. Heterologous prime-boost with the viral vectors ChAd63-MVA is the most potent inducer of T-cells in humans, demonstrating significant efficacy when ex... View more
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