publication . Doctoral thesis . 2014

Regulation of Regenerative Responses by Factors in the Extracellular Matrix during Axolotl (Ambystoma mexicanum) Limb Regeneration

Phan, Anne Quy;
Open Access English
  • Published: 01 Jan 2014
  • Publisher: eScholarship, University of California
  • Country: United States
Salamanders are unique among adult vertebrates in their ability to regenerate complex body structures after traumatic injury. Axolotl limb regeneration is a stepwise sequence of three requisite processes: (1) scarless wound healing to generate a regenerative wound epithelium, (2) blastema formation by migration, proliferation and dedifferentiation to create a mass of multipotent regeneration-competent progenitor cells, and (3) induction of pattern formation by interaction of cells with opposing positional information. The challenge to understanding how to induce and enhance regenerative ability in humans is to discover which of these processes fail in humans and...
free text keywords: Biology, Developmental biology, axolotl, ECM, heparan sulfate, limb, regeneration, salamander
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