Neuron-targeted caveolin-1 improves motor function and preserves memory in mice subjected to brain trauma

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Posadas, Edmund; Egawa, Junji; Schilling, Jan M.; Cui, Weihua; Sawadi, Atsushi; Alas, Basheer; Zemljic-Harpf, Alice E.; Fallon, McKenzie; Mandyam, Chitra D.; Roth, David M.; Patel, Hemal H.; Patel, Piyush M.; Head, Brian P.;
(2018)
  • Publisher: eScholarship, University of California
  • Subject: Medicine and Health Sciences
    mesheuropmc: cardiovascular system

Studies in vitro and in vivo demonstrate that membrane/lipid rafts (MLR) and caveolin (Cav) organize pro-growth receptors, and when over-expressed specifically in neurons, Cav-1 augments neuronal signaling and growth, and improves cognitive function in adult and aged mi... View more
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