publication . Article . Part of book or chapter of book . 2013

Synthesis and self-assembly of well-defined block copolypeptides via controlled NCA polymerization

Timothy J. Deming;
Open Access English
  • Published: 01 Jan 2013
  • Publisher: eScholarship, University of California
  • Country: United States
This article summarizes advances in the synthesis of well-defined polypeptides and block copolypeptides. Traditional methods used to polymerize α-amino acid-N-carboxyanhydrides (NCAs) are described, and limitations in the utility of these systems for the preparation of polypeptides are discussed. Improved initiators and methods that allow polypeptide synthesis with good control over chain length, chain length distribution, and chain-end functionality are also discussed. Using these methods, block and random copolypeptides of controlled dimensions (including molecular weight, sequence, composition, and molecular weight distribution) can now be prepared. The abili...
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free text keywords: Polymers, Macromolecular and Materials Chemistry, Materials Engineering, Organic Chemistry, Vesicle, Molar mass distribution, Living polymerization, Supramolecular chemistry, Materials science, Self-assembly, Micelle, Self-healing hydrogels, Combinatorial chemistry, Polymerization
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