publication . Doctoral thesis . 2011

Long-Term Plasticity of Astrocytic Metabotropic Neurotransmitter Receptors Driven by Changes in Neuronal Activity in Hippocampal Slices

Xie, Xiaoqiao;
Open Access English
  • Published: 01 Jan 2011
  • Publisher: eScholarship, University of California
  • Country: United States
Abstract
In addition to synaptic communication between neurons, there is now strong evidence for neuron-to-astrocyte receptor signaling in the brain. During trains of action potentials or repetitive stimulation, neurotransmitter spills out of the synapse to activate astrocytic Gq protein-coupled receptors (Gq GPCRs). To date, very little is known about the ability of astrocytic receptors to exhibit plasticity as a result of long-term changes in neuronal firing rates. Here we describe for the first time bidirectional scaling of astrocytic group 1 metabotropic glutamate receptor (mGluR) signaling in acute mouse hippocampal slices on a rapid timescale following either long-...
Subjects
Medical Subject Headings: nervous system
free text keywords: Neurosciences, astrocyte, Gq GPCRs, group I mGluRs, hippocampus, MrgA1, plasticity
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