publication . Doctoral thesis . 2013

Transcription-Based Molecular Imaging and Gene Therapy for Castration-resistant and Metastatic Prostate Cancer in Translational Models

Jiang, Ziyue;
Open Access English
  • Published: 01 Jan 2013
  • Publisher: eScholarship, University of California
  • Country: Mexico
The advanced stage of prostate cancer is the second leading cause of cancer-related death for American men. Novel, effective treatment options and more cancer-specific diagnostic tools are urgently needed to facilitate patient management. Here, we explored the construction and application of an array of gene-based molecular imaging and therapeutic vectors in a variety of clinically relevant settings. These vectors exploit prostate cancer-specific promoters to control the transcription of imaging reporter genes or therapeutic genes, and thus can achieve stringent cancer selectivity. We showed that gene-based imaging vectors can detect prostate cancer metastasis e...
free text keywords: Pharmacology, adenoviral vectors, castration-resistance, immunosuppression, metastasis, molecular imaging, prostate cancer
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