publication . Article . 2013

Environmental stress, oxytocin receptor gene (OXTR) polymorphism, and mental health following collective stress

Rachel G. Lucas-Thompson; E. Alison Holman;
Open Access
  • Published: 01 Apr 2013 Journal: Hormones and Behavior, volume 63, pages 615-624 (issn: 0018-506X, Copyright policy)
  • Publisher: Elsevier BV
  • Country: United States
Abstract
We examined whether the oxytocin receptor gene (OXTR) single nucleotide polymorphism (SNP) rs53576 genotype buffers the combined impact of negative social environments (e.g., interpersonal conflict/constraint) and economic stress on post-traumatic stress (PTS) symptoms and impaired daily functioning following collective stress (September 11th terrorist attacks). Saliva was collected by mail and used to genotype 704 respondents. Participants completed Web-based assessments of pre-9/11 mental health, acute stress 9-23. days after 9/11, the quality of social environments 1. year post-9/11, economic stress 18. months post-9/11, and PTS symptoms and impaired function...
Subjects
Medical Subject Headings: bacteria
free text keywords: Behavioral Neuroscience, Endocrinology, Endocrine and Autonomic Systems, Developmental psychology, Genotype, Mental health, Allele, Oxytocin receptor, SNP, Single-nucleotide polymorphism, Social environment, Clinical psychology, Sex characteristics, Psychology
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