Targeting proteasomes in infectious organisms to combat disease

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Bibo-Verdugo, B ; Jiang, Z ; Caffrey, CR ; O'Donoghue, AJ (2017)
  • Publisher: eScholarship, University of California
  • Subject: inhibitor | kinetoplastid | Mycobacterium | Plasmodium | proteasome | Schistosoma

Proteasomes are multisubunit, energy-dependent, proteolytic complexes that play an essential role in intracellular protein turnover. They are present in eukaryotes, archaea, and in some actinobacteria species. Inhibition of proteasome activity has emerged as a powerful ... View more
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