Targeting proteasomes in infectious organisms to combat disease
- Publisher: eScholarship, University of California
inhibitor | kinetoplastid | Mycobacterium | Plasmodium | proteasome | Schistosoma
Proteasomes are multisubunit, energy-dependent, proteolytic complexes that play an essential role in intracellular protein turnover. They are present in eukaryotes, archaea, and in some actinobacteria species. Inhibition of proteasome activity has emerged as a powerful ...