publication . Article . 2016

Erythrocyte-derived nano-probes functionalized with antibodies for targeted near infrared fluorescence imaging of cancer cells

Anvari, Bahman; Mac, Jenny T.; Nunez, Vicente; Burns, Joshua M.; Guerrero, Yadir A.;
Open Access English
  • Published: 01 Apr 2016
  • Publisher: eScholarship, University of California
  • Country: United States
Abstract
Constructs derived from mammalian cells are emerging as a new generation of nano-scale platforms for clinical imaging applications. Herein, we report successful engineering of hybrid nano-structures composed of erythrocyte-derived membranes doped with FDA-approved near infrared (NIR) chromophore, indocyanine green (ICG), and surface-functionalized with antibodies to achieve molecular targeting. We demonstrate that these constructs can be used for targeted imaging of cancer cells in vitro. These erythrocyte-derived optical nano-probes may provide a potential platform for clinical translation, and enable molecular imaging of cancer biomarkers.
Subjects
Medical Subject Headings: technology, industry, and agriculture
free text keywords: Engineering, Life Sciences, Fluorescence microscopy, Infrared imaging, Nanomaterials. Biomaterials, Medical and Biological Imaging
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