publication . Doctoral thesis . 2013

Engineering of Olfactory Receptor OlfCc1 for Directed Ligand Sensitivity

Berke, Allison Paige;
Open Access English
  • Published: 01 Jan 2013
  • Publisher: eScholarship, University of California
  • Country: United States
Abstract Engineering of Olfactory Receptor OlfCc1 for Directed Ligand Sensitivityby Allison Paige Berke Joint Doctor of Philosophywith the University of California San FranciscoUniversity of California, Berkeley Professor Song Li, ChairDue to structural similarity, OlfCc1and its mammalian analogue V2R2 are hypothesized to respond to amino acid ligands in a calcium-mediated fashion. By analyzing receptor structure and making targeted mutations, the specificity and sensitivity of the receptor should be tunable, within the range of OR response thresholds. OlfCc1 responds to the amino acids isoleucine and leucine, in a calcium-dependent manner. V2R2 shows a similar ...
free text keywords: Biomedical engineering, Biophysics, Biology
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