publication . Article . 2001

A biomimetic approach toward artificial bone-like materials

Bertozzi, Carolyn R.;
Open Access English
  • Published: 09 Jun 2001
  • Publisher: eScholarship, University of California
  • Country: United States
Bone consists of microcrystalline hydroxyapatite and collagen, an elastic protein matrix that is decorated with mineral-nucleating phosphoproteins. Our rational design of artificial bone-like material uses natural bone as a guide. Hydrogel and self-assembling polymers that possess anionic groups suitably positioned for nucleating biominerals, and therefore mimic the natural function of the collagen-phosphoprotein matrix in bone, were designed to direct template-driven biomimetic mineralization of hydroxyapatite. The monomer library synthesis, hydrogel and self-assembling polymer formation and structural characterization of polymer scaffolds on both micro- and na...
free text keywords: biomimetic artificial bones
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