publication . Doctoral thesis . 2008

Mechanisms of regulation in the interferon factor 3 (IRF- 3) pathway

Limmer, Kirsten;
Open Access
  • Published: 01 Jan 2008
  • Publisher: eScholarship, University of California
  • Country: United States
Abstract
Interferon regulatory factor 3 (IRF-3) plays a critical role in the host cell response to both bacterial and viral infection. IRF-3 is activated by Toll-like receptors (TLRs) and cytoplasmic nucleic acid sensors, and serves to upregulate interferon beta and interferon stimulated genes (ISGs), thereby providing a quick and effective response to infection. In this work, two novel mechanisms of regulation in the IRF-3 pathway are revealed. The first part of this thesis work shows that upon binding to lipopolysaccharide, TLR-4 signaling activates phospholipase C gamma 2 (PLCg2), which cleaves phosphatidylinositol (4,5)-bisphosphate (PIP₂) into Inositol 1,4,5-triphos...
Subjects
free text keywords: UCSD Biology. (Discipline) Dissertations, Academic, Dissertations Academic as Topic
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