publication . Article . 2018

Skin care products can aggravate epidermal function: studies in a murine model suggest a pathogenic role in sensitive skin

Li, Zhengxiao; Hu, Lizhi; Elias, Peter M; Man, Mao-Qiang;
Open Access English
  • Published: 01 Feb 2018
  • Publisher: eScholarship, University of California
Abstract
Sensitive skin is defined as a spectrum of unpleasant sensations in response to a variety of stimuli. However, only some skin care products provoke cutaneous symptoms in individuals with sensitive skin. Hence, it would be useful to identify products that could provoke cutaneous symptoms in individuals with sensitive skin.To assess whether vehicles, as well as certain branded skin care products, can alter epidermal function following topical applications to normal mouse skin.Following topical applications of individual vehicle or skin care product to C57BL/6J mice twice daily for 4 days, transepidermal water loss (TEWL) rates, stratum corneum (SC) hydration and s...
Subjects
mesheuropmc: integumentary system
free text keywords: Cutaneous, Skin Care, Inbred C57BL, Administration, adverse reactions, Dermatology & Venereal Diseases, contact dermatitis, Mice, Cosmetics, Atopic, Dermatitis, skin care products, sensitive skin, epidermal function, hydration, pH, Animals, Clinical Sciences, Female, Immunology, barrier function, Epidermis
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publication . Article . 2018

Skin care products can aggravate epidermal function: studies in a murine model suggest a pathogenic role in sensitive skin

Li, Zhengxiao; Hu, Lizhi; Elias, Peter M; Man, Mao-Qiang;