publication . Article . Other literature type . 2017

Continuous minimally-invasive alcohol monitoring using microneedle sensor arrays

Vinu Mohan, A. M.; Windmiller, Joshua Ray; Mishra, Rupesh K.; Wang, Joseph;
Open Access English
  • Published: 10 Jan 2017
  • Publisher: eScholarship, University of California
Abstract
The present work describes an attractive skin-worn microneedle sensing device for the minimally invasive electrochemical monitoring of subcutaneous alcohol. The device consists of an assembly of pyramidal microneedle structures integrated with Pt and Ag wires, each with a microcavity opening. The microneedle aperture was modified by electropolymerizing o-phenylene diamine onto the Pt wire microtransducer, followed by the immobilization of alcohol oxidase (AOx) in an intermediate chitosan layer, along with an outer Nafion layer. The resulting microneedle-based enzyme electrode displays an interference-free ethanol detection in artificial interstitial fluid withou...
Subjects
free text keywords: Chitosan, Alcohol Oxidoreductases, Needles, Minimally-invasive monitoring, Immobilized, Biosensing Techniques, Fluorocarbon Polymers, Biomedical Engineering, Skin, Enzymes, Analytical Chemistry, Mice, Ethanol, Microneedle, Platinum, Nanotechnology, Animals, Alcohol, Biosensor, Wearable sensor, Equipment Design, Extracellular Fluid, Article, Bioinformatics, Silver
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publication . Article . Other literature type . 2017

Continuous minimally-invasive alcohol monitoring using microneedle sensor arrays

Vinu Mohan, A. M.; Windmiller, Joshua Ray; Mishra, Rupesh K.; Wang, Joseph;