Why sulfonamides are contraindicated in Rocky Mountain spotted fever

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Ren, Vicky; Hsu, Sylvia;
  • Publisher: eScholarship, University of California
  • Subject: Rocky Mountain, spotted fever, Rickettsia, rickettsii, sulfa, sulfonamide, cotrimoxazole

Sulfonamide antibiotics are not effective for the treatment of Rocky Mountain spotted fever (RMSF). Patients suspected of having RMSF based on history and physical exam should be treated with doxycycline and not a sulfonamide to avoid increased morbidity and mortality.
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