publication . Doctoral thesis . 2015

Bioinformatic Analysis of Mitochondrial Pyruvate Carriers

Myers, Scott Randall;
Open Access
  • Published: 01 Jan 2015
  • Publisher: eScholarship, University of California
  • Country: United States
Abstract
The Mitochondrial Pyruvate Carrier (MPC) family of eukaryotic protein transporters reside in the mitochondrial inner-membrane and are the essential for the 150kDa transport complex of pyruvate into the mitochondrial matrix for cellular respiration. Studies in this paper show evidence that the two primary isoforms of the family, MPC1 and MPC2, both have 3-TMS topologies. Exploration of family homologies resulted in a relationship to the bidirectional sugar transporter (SWEET) family and by extension the Transporter/Opsin/G- protein (TOG) superfamily. The two families share a 41- residue sequence motif with high sequence conservation. Binary sequence alignments us...
Subjects
free text keywords: Academic Dissertations, UCSD Dissertations, Academic Biology (Discipline)
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