publication . Article . 2017

Functional Modification of Thioether Groups in Peptides, Polypeptides, and Proteins

Timothy J. Deming;
Open Access
  • Published: 01 Mar 2017 Journal: Bioconjugate Chemistry, volume 28, pages 691-700 (issn: 1043-1802, eissn: 1520-4812, Copyright policy)
  • Publisher: American Chemical Society (ACS)
  • Country: United States
Abstract
Recent developments in the modification of methionine and other thioether-containing residues in peptides, polypeptides, and proteins are reviewed. Properties and potential applications of the resulting functionalized products are also discussed. While much of this work is focused on natural Met residues, modifications at other side-chain residues have also emerged as new thioether-containing amino acids have been incorporated into peptidic materials. Functional modification of thioether-containing amino acids has many advantages and is a complementary methodology to the widely utilized methods for modification at cysteine residues.
Subjects
free text keywords: Animals, Humans, Sulfides, Peptides, Proteins, Alkylation, Oxidation-Reduction, Biochemistry and Cell Biology, Medicinal and Biomolecular Chemistry, Biotechnology, Organic Chemistry, Bioengineering, Pharmacology, Pharmaceutical Science, Biomedical Engineering, Chemistry, Biochemistry, Amino acid, chemistry.chemical_classification, Functional modification, Combinatorial chemistry, Cysteine, Thioether, chemistry.chemical_compound, Methionine
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publication . Article . 2017

Functional Modification of Thioether Groups in Peptides, Polypeptides, and Proteins

Timothy J. Deming;