publication . Doctoral thesis . 2015

Iron and Lactoferrin Levels Remain Unchanged in Parkin Deficient Mouse Brains: Implications for Parkinson’s Disease Etiology

Baker, Hanan;
Open Access English
  • Published: 01 Jan 2015
  • Publisher: eScholarship, University of California
  • Country: Mexico
Abstract
Parkinson’s disease is a devastating neurodegenerative disease in which loss of dopaminergic neurons in the substantia nigra pars compacta leads to a variety of motor and non-motor deficits. Mutations in the Park2 or parkin gene have been implicated in familial forms of Parkinson’s disease. Parkin is an E3 ubiquitin ligase that plays a role in mitophagy, the degradation of damaged mitochondria. Defects in parkin are thought to impair mitophagy, leading to mitochondrial dysfunction and an increase in oxidative stress. Although best known for its participation in the regulation of mitochondrial dynamics, parkin has also been known to play a role in cell cycle prog...
Subjects
Medical Subject Headings: nervous system diseases
free text keywords: Biochemistry, Neurosciences, Lactoferrin, Parkin, Parkinson's Disease
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