The Development and Application of Phosphine-Catalyzed Annulation Reactions: Synthetic Studies on the Total Synthesis of (±)-Reserpine and Studies Concerning Torquoselectivity

Doctoral thesis English OPEN
Barcan, Gregg;
(2012)
  • Publisher: eScholarship, University of California
  • Subject: Organic chemistry | annulations | reserpine | synthesis | torquoselectivity

A mixed double-Michael addition onto electron deficient acetylenes was developed. The reaction allows for the facile preparation of optically active oxazolidines, thiazolidines, and pyrrolidines from amino acid-derived pronucleophiles. Optimal reaction efficiencies were... View more
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