publication . Doctoral thesis . 2018

L-Type Calcium Channel Cav1.2 and Circadian Rhythms in Bipolar Disorder Patient Fibroblasts

Nudell, Victoria Shannon;
Open Access English
  • Published: 01 Jan 2018
  • Publisher: eScholarship, University of California
  • Country: United States
Abstract
Bipolar disorder (BD) is a psychiatric disorder characterized by recurrent periods of depression and mania, accompanied by major disruptions in activity and sleep patterns. The circadian clock controls these behavioral rhythms however; genome-wide association studies have failed to identify any of the essential “clock genes” that regulate rhythms as major genetic contributors in BD, but have associated the genes encoding L-type calcium channels (LTCCs) as important risk factors. CACNA1C encodes CaV1.2, a LTCC essential for entrainment of the circadian clock. In post mortem brain studies, those with BD risk-associated variants in CACNA1C show alterations in gene ...
Subjects
free text keywords: Neurosciences, Psychobiology, Cellular biology
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