publication . Article . 2005

A role for endocannabinoids in viral-induced dyskinetic and convulsive phenomena

Solbrig, MV; Adrian, R; Baratta, J; Piomelli, D; Giuffrida, A;
Open Access English
  • Published: 01 Aug 2005
  • Publisher: eScholarship, University of California
  • Country: United States
Abstract
Dyskinesias and seizures are both medically refractory disorders for which cannabinoid-based treatments have shown early promise as primary or adjunctive therapy. Using the Borna disease (BD) virus rat, an animal model of viral encephalopathy with spontaneous hyperkinetic movements and seizure susceptibility, we identified a key role for endocannabinoids in the maintenance of a balanced tone of activity in extrapyramidal and limbic circuits. BD rats showed significant elevations of the endocannabinoid anandamide in subthalamic nucleus, a relay nucleus compromised in hyperkinetic disorders. While direct and indirect cannabinoid agonists had limited motor effects ...
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