publication . Doctoral thesis . 2017

Establishing a Proper Model of Tobacco Dependence: Influence of Age and Tobacco Smoke Constituents

Gellner, Candice Ann;
Open Access English
  • Published: 01 Jan 2017
  • Publisher: eScholarship, University of California
  • Country: United States
Abstract
Cigarette smoking is the leading preventable cause of death in the United States. Of those who smoke, 9 out of 10 report trying their first cigarette before the age of 18. Although most people who initiate tobacco use are teenagers, animal models for studying tobacco dependence have traditionally focused on how adult animals initiate, withdrawal from and relapse to cigarette smoking. Furthermore, cigarette smoke contains more than 7,000 constituents, including nicotine, yet pre-clinical research has focused on nicotine alone. Our lab began studying these constituents by creating cigarette smoke extract, CSE, a solution which contains the aqueous constituents pre...
Subjects
free text keywords: Pharmacology
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