Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis.

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Lotta, Luca A.; Scott, Robert A.; Sharp, Stephen J.; Burgess, Stephen; Luan, Jian’an; Tillin, Therese; Schmidt, Amand F.; Imamura, Fumiaki; Stewart, Isobel D.; Perry, John R. B.; Marney, Luke; Koulman, Albert; Karoly, Edward D.; Forouhi, Nita G.; Sjögren, Rasmus J. O.; Näslund, Erik; Zierath, Juleen R.; Krook, Anna; Savage, David B.; Griffin, Julian L.; Chaturvedi, Nishi; Hingorani, Aroon D.; Khaw, Kay-Tee; Barroso, Inês; McCarthy, Mark I.; O’Rahilly, Stephen; Wareham, Nicholas J.; Langenberg, Claudia;
(2016)
  • Publisher: Public Library of Science (PLoS)
  • Journal: PLoS Medicine,volume 13,issue 11 (issn: 1549-1277, eissn: 1549-1676)
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.17863/CAM.7150, doi: 10.1371/journal.pmed.1002179, pmc: PMC5127513
  • Subject: Molecular Biology | Research Article | Molecular Biology Assays and Analysis Techniques | Mathematics | Amino Acids | Amino Acid Analysis | Diabetes Mellitus | Mathematical and Statistical Techniques | Endocrine Disorders | Isoleucine | Genetic Loci | Chemical Compounds | Genetics | Physical Sciences | Organic Chemistry | Proteins | Molecular Biology Techniques | Aliphatic Amino Acids | Metabolic Pathways | Chemistry | Leucine | Metabolic Disorders | Statistics (Mathematics) | Biology and Life Sciences | Research and Analysis Methods | Meta-Analysis | Medicine | Type 2 diabetes, Genetic loci, Isoleucine, Amino acid analysis, Meta-analysis, Leucine, Metabolic pathways, Valin | R | Type 2 Diabetes | Biochemistry | Valine | Metabolism | Medicine and Health Sciences | Organic Compounds | Statistical Methods | Endocrinology

$\textbf{BACKGROUND}$: Higher circulating levels of the branched-chain amino acids (BCAAs; i.e., isoleucine, leucine, and valine) are strongly associated with higher type 2 diabetes risk, but it is not known whether this association is causal. We undertook large-scale h... View more