publication . Article . 2014

The regulation and deregulation of Wnt signalling by PARK genes in health and disease.

Berwick, D. C.; Harvey, K.;
Open Access
  • Published: 01 Feb 2014
  • Country: United Kingdom
Abstract
Wingless/Int (Wnt) signalling pathways are signal transduction mechanisms that have been widely studied in the field of embryogenesis. Recent work has established a critical role for these pathways in brain development, especially of midbrain dopaminergic neurones. However, the fundamental importance of Wnt signalling for the normal function of mature neurones in the adult central nervous system has also lately been demonstrated by an increasing number of studies. Parkinson's disease (PD) is the second most prevalent neurodegenerative disease worldwide and is currently incurable. This debilitating disease is characterized by the progressive loss of a subset of m...
Subjects
free text keywords: LRRK2, Parkinson's disease, Wnt signalling, genetics of Parkinson's disease, neurodegeneration, treatment
Funded by
WT| LRRK2 modulation of Wnt signalling cascades in Parkinson's disease.
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 095010
  • Funding stream: Neuroscience and Mental Health
,
WT| Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt pathways.
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 088145
  • Funding stream: Neuroscience and Mental Health
Download from
UCL Discovery
Article . 2014
125 references, page 1 of 9

Alves dos Santos, M.T., and Smidt, M.P. (2011). En1 and Wnt signaling in midbrain dopaminergic neuronal development. Neural. Dev. 6, 23.

Arenas, E. (2005). Engineering a dopaminergic phenotype in stem/precursor cells: role of Nurr1, glia-derived signals, and Wnts. Ann. NY Acad. Sci. 1049, 51 -66.

Belenkaya, T.Y., Wu, Y., Tang, X., et al. (2008). The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network. Dev. Cell 14, 120 - 131. [OpenAIRE]

Berwick, D.C., and Harvey, K. (2011). LRRK2 signaling pathways: the key to unlocking neurodegeneration? Trends Cell Biol. 21, 257 - 265.

Berwick, D.C., and Harvey, K. (2012a). LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6. Hum. Mol. Genet. 21, 4966 - 4979. [OpenAIRE]

Berwick, D.C., and Harvey, K. (2012b). The importance of Wnt signalling for neurodegeneration in Parkinson's disease. Biochem. Soc. Trans. 40, 1123- 1128. [OpenAIRE]

Berwick, D.C., and Harvey, K. (2013). LRRK2: an e´minence grise of Wnt-mediated neurogenesis? Front. Cell. Neurosci. 7, 82.

Biskup, S., Moore, D.J., Celsi, F., et al. (2006). Localization of LRRK2 to membranous and vesicular structures in mammalian brain. Ann. Neurol. 60, 557 - 569.

Brault, V., Moore, R., Kutsch, S., et al. (2001). Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 128, 1253- 1264.

Caffrey, T.M., and Wade-Martins, R. (2007). Functional MAPT haplotypes: bridging the gap between genotype and neuropathology. Neurobiol. Dis. 27, 1 -10.

Cantuti-Castelvetri, I., Keller-McGandy, C., Bouzou, B., et al. (2007). Effects of gender on nigral gene expression and parkinson disease. Neurobiol. Dis. 26, 606 - 614. [OpenAIRE]

Caricasole, A., Copani, A., Caraci, F., et al. (2004). Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain. J. Neurosci. 24, 6021- 6027. [OpenAIRE]

Carpenter, A.C., Rao, S., Wells, J.M., et al. (2010). Generation of mice with a conditional null allele for Wntless. Genesis 48, 554- 558.

Castan˜o, Z., Gordon-Weeks, P.R., and Kypta, R.M. (2010). The neuron-specific isoform of glycogen synthase kinase-3beta is required for axon growth. J. Neurochem. 113, 117 - 130.

Castelo-Branco, G., and Arenas, E. (2006). Function of Wnts in dopaminergic neuron development. Neurodegener. Dis. 3, 5 -11.

125 references, page 1 of 9
Abstract
Wingless/Int (Wnt) signalling pathways are signal transduction mechanisms that have been widely studied in the field of embryogenesis. Recent work has established a critical role for these pathways in brain development, especially of midbrain dopaminergic neurones. However, the fundamental importance of Wnt signalling for the normal function of mature neurones in the adult central nervous system has also lately been demonstrated by an increasing number of studies. Parkinson's disease (PD) is the second most prevalent neurodegenerative disease worldwide and is currently incurable. This debilitating disease is characterized by the progressive loss of a subset of m...
Subjects
free text keywords: LRRK2, Parkinson's disease, Wnt signalling, genetics of Parkinson's disease, neurodegeneration, treatment
Funded by
WT| LRRK2 modulation of Wnt signalling cascades in Parkinson's disease.
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 095010
  • Funding stream: Neuroscience and Mental Health
,
WT| Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt pathways.
Project
  • Funder: Wellcome Trust (WT)
  • Project Code: 088145
  • Funding stream: Neuroscience and Mental Health
Download from
UCL Discovery
Article . 2014
125 references, page 1 of 9

Alves dos Santos, M.T., and Smidt, M.P. (2011). En1 and Wnt signaling in midbrain dopaminergic neuronal development. Neural. Dev. 6, 23.

Arenas, E. (2005). Engineering a dopaminergic phenotype in stem/precursor cells: role of Nurr1, glia-derived signals, and Wnts. Ann. NY Acad. Sci. 1049, 51 -66.

Belenkaya, T.Y., Wu, Y., Tang, X., et al. (2008). The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network. Dev. Cell 14, 120 - 131. [OpenAIRE]

Berwick, D.C., and Harvey, K. (2011). LRRK2 signaling pathways: the key to unlocking neurodegeneration? Trends Cell Biol. 21, 257 - 265.

Berwick, D.C., and Harvey, K. (2012a). LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6. Hum. Mol. Genet. 21, 4966 - 4979. [OpenAIRE]

Berwick, D.C., and Harvey, K. (2012b). The importance of Wnt signalling for neurodegeneration in Parkinson's disease. Biochem. Soc. Trans. 40, 1123- 1128. [OpenAIRE]

Berwick, D.C., and Harvey, K. (2013). LRRK2: an e´minence grise of Wnt-mediated neurogenesis? Front. Cell. Neurosci. 7, 82.

Biskup, S., Moore, D.J., Celsi, F., et al. (2006). Localization of LRRK2 to membranous and vesicular structures in mammalian brain. Ann. Neurol. 60, 557 - 569.

Brault, V., Moore, R., Kutsch, S., et al. (2001). Inactivation of the beta-catenin gene by Wnt1-Cre-mediated deletion results in dramatic brain malformation and failure of craniofacial development. Development 128, 1253- 1264.

Caffrey, T.M., and Wade-Martins, R. (2007). Functional MAPT haplotypes: bridging the gap between genotype and neuropathology. Neurobiol. Dis. 27, 1 -10.

Cantuti-Castelvetri, I., Keller-McGandy, C., Bouzou, B., et al. (2007). Effects of gender on nigral gene expression and parkinson disease. Neurobiol. Dis. 26, 606 - 614. [OpenAIRE]

Caricasole, A., Copani, A., Caraci, F., et al. (2004). Induction of Dickkopf-1, a negative modulator of the Wnt pathway, is associated with neuronal degeneration in Alzheimer's brain. J. Neurosci. 24, 6021- 6027. [OpenAIRE]

Carpenter, A.C., Rao, S., Wells, J.M., et al. (2010). Generation of mice with a conditional null allele for Wntless. Genesis 48, 554- 558.

Castan˜o, Z., Gordon-Weeks, P.R., and Kypta, R.M. (2010). The neuron-specific isoform of glycogen synthase kinase-3beta is required for axon growth. J. Neurochem. 113, 117 - 130.

Castelo-Branco, G., and Arenas, E. (2006). Function of Wnts in dopaminergic neuron development. Neurodegener. Dis. 3, 5 -11.

125 references, page 1 of 9
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