publication . Article . Other literature type . 2012

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

Dastani, Zari; Hivert, Marie-France; Timpson, Nicholas; Perry, John; Yuan, Xin; Scott, Robert; Henneman, Peter; Heid, Iris M; Kizer, Jorge R; Lyytikäinen, Leo-Pekka; ...
  • Published: 01 Mar 2012
Abstract
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10−8–1.2×10−43). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression a...
Subjects
free text keywords: Adiponectin/blood; Adiponectin/genetics; African Americans; Asian Continental Ancestry Group; Cholesterol, HDL/genetics; Diabetes Mellitus, Type 2/genetics; European Continental Ancestry Group; Female; Gene Expression; Genetic Predisposition to Disease; Genome-Wide Association Study; Glucose Tolerance Test; Humans; Insulin Resistance/genetics; Male; Metabolic Networks and Pathways; Polymorphism, Single Nucleotide; Waist-Hip Ratio, DIAGRAM+ Consortium, MAGIC Consortium, GLGC Investigators, MuTHER Consortium, DIAGRAM Consortium, GIANT Consortium, Global B Pgen Consortium, Procardis Consortium, MAGIC investigators, GLGC Consortium, Humans, Diabetes Mellitus, Type 2, Insulin Resistance, Genetic Predisposition to Disease, Glucose Tolerance Test, Waist-Hip Ratio, Gene Expression, Polymorphism, Single Nucleotide, African Americans, Asian Continental Ancestry Group, European Continental Ancestry Group, Female, Male, Adiponectin, Cholesterol, HDL, Metabolic Networks and Pathways, Genome-Wide Association Study, Genetics, Developmental Biology, /dk/atira/pure/subjectarea/asjc/1100/1105, Ecology, Evolution, Behavior and Systematics, /dk/atira/pure/subjectarea/asjc/1300/1311, /dk/atira/pure/subjectarea/asjc/1300/1312, Molecular Biology, /dk/atira/pure/subjectarea/asjc/2700/2716, Genetics(clinical), /dk/atira/pure/subjectarea/asjc/1300/1306, Cancer Research, Medizin, Biolääketieteet - Biomedicine, GENOME-WIDE ASSOCIATION, CORONARY-ARTERY-DISEASE, INSULIN-RESISTANCE, LIPID CONCENTRATIONS, ADIPOSE-TISSUE, GENETIC-BASIS, RISK, POPULATION, RECEPTOR, VARIANTS, 3121 Internal medicine, 3111 Biomedicine, Diabetes Mellitus, Type 2, Polymorphism, Single Nucleotide, Cholesterol, HDL, Research Article, Biology, Human Genetics, Molecular Genetics, Medicine, Clinical Research Design, Adiponectin, African Americans, Asian Continental Ancestry Group, Cholesterol, HDL, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Gene Expression, Genetic Predisposition to Disease, Genome-Wide Association Study, Glucose Tolerance Test, Humans, Insulin Resistance, Male, Metabolic Networks and Pathways, Polymorphism, Single Nucleotide, Waist-Hip Ratio, Science & Technology, Life Sciences & Biomedicine, Genetics & Heredity, 0604 Genetics, QH426-470, ddc:610
56 references, page 1 of 4

Hivert, MF, Sullivan, LM, Fox, CS, Nathan, DM, D'Agostino, RB. Associations of adiponectin, resistin, and tumor necrosis factor-alpha with insulin resistance.. J Clin Endocrinol Metab. 2008; 93: 3165-3172 [OpenAIRE] [PubMed]

Tilg, H, Moschen, AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity.. Nat Rev Immunol. 2006; 6: 772-783 [OpenAIRE] [PubMed]

Pischon, T, Girman, CJ, Hotamisligil, GS, Rifai, N, Hu, FB. Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men.. JAMA: The Journal of the American Medical Association. 2004; 291: 1730-1737 [OpenAIRE] [PubMed]

Li, S, Shin, HJ, Ding, EL, van Dam, RM. Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis.. JAMA. 2009; 302: 179-188 [PubMed]

Stumvoll, M, Goldstein, BJ, van Haeften, TW. Type 2 diabetes: principles of pathogenesis and therapy.. Lancet. 2005; 365: 1333-1346 [OpenAIRE] [PubMed]

Nawrocki, AR, Rajala, MW, Tomas, E, Pajvani, UB, Saha, AK. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists.. J Biol Chem. 2006; 281: 2654-2660 [PubMed]

Wang, Y, Zhou, M, Lam, KS, Xu, A. Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implications.. Arq Bras Endocrinol Metabol. 2009; 53: 201-212 [PubMed]

Comuzzie, AG, Funahashi, T, Sonnenberg, G, Martin, LJ, Jacob, HJ. The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome.. Journal of Clinical Endocrinology and Metabolism. 2001; 86: 4321-4325 [OpenAIRE] [PubMed]

Vasseur, F, Helbecque, N, Dina, C, Lobbens, S, Delannoy, V. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians.. Hum Mol Genet. 2002; 11: 2607-2614 [PubMed]

Cesari, M, Narkiewicz, K, De Toni, R, Aldighieri, E, Williams, CJ. Heritability of plasma adiponectin levels and body mass index in twins.. J Clin Endocrinol Metab. 2007; 92: 3082-3088 [OpenAIRE] [PubMed]

Liu, PH, Jiang, YD, Chen, WJ, Chang, CC, Lee, TC. Genetic and environmental influences on adiponectin, leptin, and BMI among adolescents in Taiwan: a multivariate twin/sibling analysis.. Twin Res Hum Genet. 2008; 11: 495-504 [PubMed]

Menzaghi, C, Trischitta, V, Doria, A. Genetic influences of adiponectin on insulin resistance, type 2 diabetes, and cardiovascular disease.. Diabetes. 2007; 56: 1198-1209 [OpenAIRE] [PubMed]

Hivert, MF, Manning, AK, McAteer, JB, Florez, JC, Dupuis, J. Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study.. Diabetes. 2008; 57: 3353-3359 [OpenAIRE] [PubMed]

Ling, H, Waterworth, DM, Stirnadel, HA, Pollin, TI, Barter, PJ. Genome-wide Linkage and Association Analyses to Identify Genes Influencing Adiponectin Levels: The GEMS Study.. Obesity (Silver Spring). 2009 [OpenAIRE]

Heid, IM, Henneman, P, Hicks, A, Coassin, S, Winkler, T. Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals.. Atherosclerosis. 2010; 208: 412-420 [OpenAIRE] [PubMed]

56 references, page 1 of 4
Abstract
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P = 4.5×10−8–1.2×10−43). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression a...
Subjects
free text keywords: Adiponectin/blood; Adiponectin/genetics; African Americans; Asian Continental Ancestry Group; Cholesterol, HDL/genetics; Diabetes Mellitus, Type 2/genetics; European Continental Ancestry Group; Female; Gene Expression; Genetic Predisposition to Disease; Genome-Wide Association Study; Glucose Tolerance Test; Humans; Insulin Resistance/genetics; Male; Metabolic Networks and Pathways; Polymorphism, Single Nucleotide; Waist-Hip Ratio, DIAGRAM+ Consortium, MAGIC Consortium, GLGC Investigators, MuTHER Consortium, DIAGRAM Consortium, GIANT Consortium, Global B Pgen Consortium, Procardis Consortium, MAGIC investigators, GLGC Consortium, Humans, Diabetes Mellitus, Type 2, Insulin Resistance, Genetic Predisposition to Disease, Glucose Tolerance Test, Waist-Hip Ratio, Gene Expression, Polymorphism, Single Nucleotide, African Americans, Asian Continental Ancestry Group, European Continental Ancestry Group, Female, Male, Adiponectin, Cholesterol, HDL, Metabolic Networks and Pathways, Genome-Wide Association Study, Genetics, Developmental Biology, /dk/atira/pure/subjectarea/asjc/1100/1105, Ecology, Evolution, Behavior and Systematics, /dk/atira/pure/subjectarea/asjc/1300/1311, /dk/atira/pure/subjectarea/asjc/1300/1312, Molecular Biology, /dk/atira/pure/subjectarea/asjc/2700/2716, Genetics(clinical), /dk/atira/pure/subjectarea/asjc/1300/1306, Cancer Research, Medizin, Biolääketieteet - Biomedicine, GENOME-WIDE ASSOCIATION, CORONARY-ARTERY-DISEASE, INSULIN-RESISTANCE, LIPID CONCENTRATIONS, ADIPOSE-TISSUE, GENETIC-BASIS, RISK, POPULATION, RECEPTOR, VARIANTS, 3121 Internal medicine, 3111 Biomedicine, Diabetes Mellitus, Type 2, Polymorphism, Single Nucleotide, Cholesterol, HDL, Research Article, Biology, Human Genetics, Molecular Genetics, Medicine, Clinical Research Design, Adiponectin, African Americans, Asian Continental Ancestry Group, Cholesterol, HDL, Diabetes Mellitus, Type 2, European Continental Ancestry Group, Female, Gene Expression, Genetic Predisposition to Disease, Genome-Wide Association Study, Glucose Tolerance Test, Humans, Insulin Resistance, Male, Metabolic Networks and Pathways, Polymorphism, Single Nucleotide, Waist-Hip Ratio, Science & Technology, Life Sciences & Biomedicine, Genetics & Heredity, 0604 Genetics, QH426-470, ddc:610
56 references, page 1 of 4

Hivert, MF, Sullivan, LM, Fox, CS, Nathan, DM, D'Agostino, RB. Associations of adiponectin, resistin, and tumor necrosis factor-alpha with insulin resistance.. J Clin Endocrinol Metab. 2008; 93: 3165-3172 [OpenAIRE] [PubMed]

Tilg, H, Moschen, AR. Adipocytokines: mediators linking adipose tissue, inflammation and immunity.. Nat Rev Immunol. 2006; 6: 772-783 [OpenAIRE] [PubMed]

Pischon, T, Girman, CJ, Hotamisligil, GS, Rifai, N, Hu, FB. Plasma Adiponectin Levels and Risk of Myocardial Infarction in Men.. JAMA: The Journal of the American Medical Association. 2004; 291: 1730-1737 [OpenAIRE] [PubMed]

Li, S, Shin, HJ, Ding, EL, van Dam, RM. Adiponectin levels and risk of type 2 diabetes: a systematic review and meta-analysis.. JAMA. 2009; 302: 179-188 [PubMed]

Stumvoll, M, Goldstein, BJ, van Haeften, TW. Type 2 diabetes: principles of pathogenesis and therapy.. Lancet. 2005; 365: 1333-1346 [OpenAIRE] [PubMed]

Nawrocki, AR, Rajala, MW, Tomas, E, Pajvani, UB, Saha, AK. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists.. J Biol Chem. 2006; 281: 2654-2660 [PubMed]

Wang, Y, Zhou, M, Lam, KS, Xu, A. Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implications.. Arq Bras Endocrinol Metabol. 2009; 53: 201-212 [PubMed]

Comuzzie, AG, Funahashi, T, Sonnenberg, G, Martin, LJ, Jacob, HJ. The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome.. Journal of Clinical Endocrinology and Metabolism. 2001; 86: 4321-4325 [OpenAIRE] [PubMed]

Vasseur, F, Helbecque, N, Dina, C, Lobbens, S, Delannoy, V. Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians.. Hum Mol Genet. 2002; 11: 2607-2614 [PubMed]

Cesari, M, Narkiewicz, K, De Toni, R, Aldighieri, E, Williams, CJ. Heritability of plasma adiponectin levels and body mass index in twins.. J Clin Endocrinol Metab. 2007; 92: 3082-3088 [OpenAIRE] [PubMed]

Liu, PH, Jiang, YD, Chen, WJ, Chang, CC, Lee, TC. Genetic and environmental influences on adiponectin, leptin, and BMI among adolescents in Taiwan: a multivariate twin/sibling analysis.. Twin Res Hum Genet. 2008; 11: 495-504 [PubMed]

Menzaghi, C, Trischitta, V, Doria, A. Genetic influences of adiponectin on insulin resistance, type 2 diabetes, and cardiovascular disease.. Diabetes. 2007; 56: 1198-1209 [OpenAIRE] [PubMed]

Hivert, MF, Manning, AK, McAteer, JB, Florez, JC, Dupuis, J. Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study.. Diabetes. 2008; 57: 3353-3359 [OpenAIRE] [PubMed]

Ling, H, Waterworth, DM, Stirnadel, HA, Pollin, TI, Barter, PJ. Genome-wide Linkage and Association Analyses to Identify Genes Influencing Adiponectin Levels: The GEMS Study.. Obesity (Silver Spring). 2009 [OpenAIRE]

Heid, IM, Henneman, P, Hicks, A, Coassin, S, Winkler, T. Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals.. Atherosclerosis. 2010; 208: 412-420 [OpenAIRE] [PubMed]

56 references, page 1 of 4
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publication . Article . Other literature type . 2012

Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals

Dastani, Zari; Hivert, Marie-France; Timpson, Nicholas; Perry, John; Yuan, Xin; Scott, Robert; Henneman, Peter; Heid, Iris M; Kizer, Jorge R; Lyytikäinen, Leo-Pekka; ...