publication . Article . 2016

A Simplified Model of Glycoprotein Production within Cell Culture

ANNA B. LAMBERT; FRANK T. SMITH; AJOY VELAYUDHAN;
Open Access English
  • Published: 19 Oct 2016
  • Publisher: Cambridge University Press (CUP)
  • Country: United Kingdom
Abstract
<jats:p>Complex biological products, such as those used to treat various forms of cancer, are typically produced by mammalian cells in bioreactors. The most important class of such biological medicines is proteins. These typically bind to sugars (glycans) in a process known as glycosylation, creating glycoproteins, which are more stable and effective medicines. The glycans are large polymers that are formed by a long sequence of enzyme catalysed reactions. This sequence is not always completed, thus leading to a heterogeneous glycoprotein distribution. A better comprehension of this distribution could lead to more efficient production of high quality drugs. To u...
Subjects
free text keywords: Mathematical Model, Glycosylation, Post-translational modification, Bioreactor, Applied Mathematics, Glycan, biology.protein, biology, Cell culture, Bioreactor, Steady state, Glycosylation, chemistry.chemical_compound, chemistry, Mathematical analysis, Biological system, Time evolution, Ode, Glycoprotein, chemistry.chemical_classification, Mathematics
Related Organizations
29 references, page 1 of 2

[1]Aris, R. (1989) Reactions in continuous mixtures. AIChE Journal 35(4), 539{548.

[2]Aris, R. & Gavalas, G. (1966) On the theory of reactions in continuous mixtures.

Philosophical Transactions of the Royal Society A 260(1112), 351{393.

[3]Arnold, J. N., Wormald, M. R., Sim, R. B., Rudd, P. M., & Dwek, R. A.

(2007) The impact of glycosylation on the biological function and structure of human immunoglobulins. Annual Review of Immunology 25(1), 21{50.

[4]Band, L. R. & King, J. R. (2012) Multiscale modelling of auxin transport in the plant-root elongation zone. Journal of Mathematical Biology 65(4), 743{85.

[5]Boreskov, G. K. & Matros, Y. S. (2006) Unsteady-State Performance of Heterogeneous Catalytic Reactions. Catalysis Reviews 25(4), 551{590.

[6]Bruns, D. & Bailey, J. (1975) Process operation near an unstable steady state using nonlinear feedback control. Chemical Engineering Science 30(7), 755{762.

[7]Chou, M. Y. & Ho, T. C. (1989) Lumping coupled nonlinear reactions in continuous mixtures. AIChE Journal 35(4), 533{538.

[8]Dimitrov, D. S. (2012) Therapeutic proteins., volume 899. Humana Press, New York.

[9]Edelstein-Keshet, L. (1988) Mathematical Models in Biology. SIAM, Philadelphia, Pennsylvania.

[10]Elliott, S., Lorenzini, T., Asher, S., Aoki, K., Brankow, D., Buck, L., Busse, L., Chang, D., Fuller, J., Grant, J., Hernday, N., Hokum, M., Hu, S., Knudten, A., Levin, N., Komorowski, R., Martin, F., Navarro, R., Osslund, T., Rogers, G., Rogers, N., Trail, G., & Egrie, J. (2003) Enhancement of therapeutic protein in vivo activities through glycoengineering. Nature Biotechnology 21(4), 414{21.

[11]Hossler, P., Khattak, S. F., & Li, Z. J. (2009) Optimal and consistent protein glycosylation in mammalian cell culture. Glycobiology 19(9), 936{49. [OpenAIRE]

[12]Hossler, P., Mulukutla, B. C., & Hu, W.-S. (2007) Systems analysis of N-glycan processing in mammalian cells. PLOS ONE 2(8), e713. [OpenAIRE]

[13]Jimenez del Val, I., Nagy, J. M., & Kontoravdi, C. (2011) A dynamic mathematical model for monoclonal antibody N-linked glycosylation and nucleotide sugar donor transport within a maturing Golgi apparatus. Biotechnology progress 27(6), 1730{43.

29 references, page 1 of 2
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publication . Article . 2016

A Simplified Model of Glycoprotein Production within Cell Culture

ANNA B. LAMBERT; FRANK T. SMITH; AJOY VELAYUDHAN;