publication . Article . 2016

A Simplified Model of Glycoprotein Production within Cell Culture

Open Access English
  • Published: 19 Oct 2016
  • Publisher: Cambridge University Press (CUP)
  • Country: United Kingdom
<jats:p>Complex biological products, such as those used to treat various forms of cancer, are typically produced by mammalian cells in bioreactors. The most important class of such biological medicines is proteins. These typically bind to sugars (glycans) in a process known as glycosylation, creating glycoproteins, which are more stable and effective medicines. The glycans are large polymers that are formed by a long sequence of enzyme catalysed reactions. This sequence is not always completed, thus leading to a heterogeneous glycoprotein distribution. A better comprehension of this distribution could lead to more efficient production of high quality drugs. To u...
free text keywords: Mathematical Model, Glycosylation, Post-translational modification, Bioreactor, Applied Mathematics, Glycan, biology.protein, biology, Cell culture, Bioreactor, Steady state, Glycosylation, chemistry.chemical_compound, chemistry, Mathematical analysis, Biological system, Time evolution, Ode, Glycoprotein, chemistry.chemical_classification, Mathematics
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publication . Article . 2016

A Simplified Model of Glycoprotein Production within Cell Culture