A Simplified Model of Glycoprotein Production within Cell Culture

Article English OPEN
Lambert, A. B.; Smith, F. T.; Velayudhan, A.;
(2017)
  • Publisher: Cambridge University Press (CUP)
  • Subject: Mathematical Model, Glycosylation, Post-translational modification, Bioreactor

Complex biological products, such as those used to treat various forms of cancer, are typically produced by mammalian cells in bioreactors. The most important class of such biological medicines is proteins. These typically bind to sugars (glycans) in a process known as ... View more
  • References (29)
    29 references, page 1 of 3

    [1]Aris, R. (1989) Reactions in continuous mixtures. AIChE Journal 35(4), 539{548.

    [2]Aris, R. & Gavalas, G. (1966) On the theory of reactions in continuous mixtures.

    Philosophical Transactions of the Royal Society A 260(1112), 351{393.

    [3]Arnold, J. N., Wormald, M. R., Sim, R. B., Rudd, P. M., & Dwek, R. A.

    (2007) The impact of glycosylation on the biological function and structure of human immunoglobulins. Annual Review of Immunology 25(1), 21{50.

    [4]Band, L. R. & King, J. R. (2012) Multiscale modelling of auxin transport in the plant-root elongation zone. Journal of Mathematical Biology 65(4), 743{85.

    [5]Boreskov, G. K. & Matros, Y. S. (2006) Unsteady-State Performance of Heterogeneous Catalytic Reactions. Catalysis Reviews 25(4), 551{590.

    [6]Bruns, D. & Bailey, J. (1975) Process operation near an unstable steady state using nonlinear feedback control. Chemical Engineering Science 30(7), 755{762.

    [7]Chou, M. Y. & Ho, T. C. (1989) Lumping coupled nonlinear reactions in continuous mixtures. AIChE Journal 35(4), 533{538.

    [8]Dimitrov, D. S. (2012) Therapeutic proteins., volume 899. Humana Press, New York.

  • Related Research Results (1)
  • Metrics
Share - Bookmark

  • Download from
  • Cite this publication