Finding Direction in the Search for Selection

Article English OPEN
Thiltgen, Grant; dos Reis, Mario; Goldstein, Richard A.;
  • Publisher: Springer US
  • Journal: Journal of Molecular Evolution,volume 84,issue 1,pages39-50 (issn: 0022-2844, eissn: 1432-1432)
  • Related identifiers: doi: 10.13039/501100000265, doi: 10.1007/s00239-016-9765-5, pmc: PMC5253163
  • Subject: Molecular Biology | Original Article | Genetics | Diversifying selection | dN/dS | Directional selection, Diversifying selection, Positive selection, dN/dS | Directional selection | Ecology, Evolution, Behavior and Systematics | Positive selection

Tests for positive selection have mostly been developed to look for diversifying selection where change away from the current amino acid is often favorable. However, in many cases we are interested in directional selection where there is a shift toward specific amino ac... View more
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