publication . Article . 2014

Receptor Kinase AXL is Modulated in the Osteogenic Differentiation of Human Mesenchymal Stromal Cells on Modified Titanium Implant Surfaces

Ramine Khan, M.;
Open Access English
  • Published: 14 Sep 2014
Abstract
Titanium (Ti) implants with micro-rough topography and high surface free energy promote osseointegration, which in vitro analyses suggest is due to a novel enhancement in cellular osteogenic differentiation and function. The AXL receptor tyrosine kinase (AXL) is expressed on mesenchymal stromal cells (MSCs) and is implicated with its ligand, Growth arrest-specific 6 (GAS6), in the negative regulation of osteogenic differentiation, and may be modulated in the enhanced osteogenic differentiation of MSCs on modified Ti surfaces. This hypothesis was tested by culturing human MSCs on tissue culture plastic (TCP), polished (P), micro-rough-hydrophobic (SLA) and micro-...
Subjects
free text keywords: AXL; GAS6; Mesenchymal stromal cells; Adult stem cell; Osteogenesis; Titanium implants
Download from
UCL Discovery
Article . 2014
28 references, page 1 of 2

1. Liu X, Chu P, Ding C (2004) Surface modification of titanium, titanium alloys, and related materials for biomedical applications. Mat Sci Eng 47: 91-121.

2. Wennerberg A, Albrektsson T (2009) Effects of titanium surface topography on bone integration: a systematic review. Clin Oral Impl Res 20: 172-182. [PubMed]

3. Zhao G, Raines A, Wieland M, Schwartz Z, Boyan B (2007) Requirement for both micron and sub-micron scale structure for synergistic responses of osteoblasts to substrate energy and topography. Biomat 31: 2728-2735. [PubMed]

4. Rausch-Fan X, Qu Z, Wieland M, Matejka M, Schedle A (2007) Differentiation and cytokine synthesis of human alveolar osteoblasts compared to osteoblast like cells in response to titanium surfaces. Dent Mater 24: 102-110. [PubMed]

5. Brett P, Harle J, Salih V, Mihoc R, Olsen I, et al. (2004) Roughness response genes in osteoblasts. Bone 35: 124-133. [PubMed]

6. Rupp F, Schneider C, Olshanska N, de Wild M, Wieland M, et al. (2006) Enhancing surface free energy and hydrophilicity through chemical modification of microstructured titanium implant surfaces. J Biomed Mater Res 76: 323-334. [PubMed]

7. Schwartz F, Wieland M, Schwartz Z, Zhao G, Rupp F, et al. (2009) Potential of chemically modified hydrophilic surface characteristics to support tissue integration of titanium dental implants. J Biomedi Mat Res 88: 544-557. [PubMed]

8. Bornstein M, Wittneben J, Bragger U, Buser D (2010) Early loding at 21 days of non-submerged titanium implamts with a chemically modified sandblasted and acid-etched surface: 3-year results of a prospective study in the posterior mandible. J Periodontal 81: 809-818. [PubMed]

9. Schwartz F, Sager M, Kadeka I, Ferrari D, Becker J (2010) Influence of titanium implant surface characteristics on bone regeneration in dehiscence type defects: an experimental study in dogs. J Clin Periodontol 37: 466-473. [PubMed]

10. Lang N, Salvi G, Huynh-Ba G, Ivanovski S, Donos N, et al. (2011) Early osseointegration to hydrophilic and hydrophobic implant surfaces in humans. Clin Oral Impl Res 22: 349-356. [PubMed]

11. Bosshardt D, Salvi G, Huynh-Ba G, Ivanovski S, Donos N, et al. (2011) The role of bone debris in early healing adjacent to hydrophilic and hydrophobic implant surfaces in man. Clin Oral Impl Res 22: 357-364. [PubMed]

12. Donos N, Hamlet S, Lang N, Salvi G, Huynh-Ba G, et al. (2011) Gene expression profile of Gene expression profile of compared with a hydrophobic microrough implant surface. Clin Oral Impl Red 22: 365-372. [PubMed]

13. Ivanovski S, Hamlet S, Salvi G, Huynh-Ba G, Bosshardt D, et al. (2011) Transcriptional profiling of osseointegration in humans. Clin Oral Impl Res 22: 378-381. [PubMed]

14. Ivanovski S, Hamlet S, Retzepi M, Wall I, Donos N (2011) Transcriptional profiling of “guided bone regeneration” in a critical-size calvarial defect. Clin Oral Impl Res 22: 382-389. [PubMed]

15. Wall I, Donos N, Calqvist K, Jones F, Brett P (2009) Modified titanium surfaces promote accelerated osteogenic differentiation of mesenchymal stromal cells in vitro. Bone 45: 17-26. [PubMed]

28 references, page 1 of 2
Abstract
Titanium (Ti) implants with micro-rough topography and high surface free energy promote osseointegration, which in vitro analyses suggest is due to a novel enhancement in cellular osteogenic differentiation and function. The AXL receptor tyrosine kinase (AXL) is expressed on mesenchymal stromal cells (MSCs) and is implicated with its ligand, Growth arrest-specific 6 (GAS6), in the negative regulation of osteogenic differentiation, and may be modulated in the enhanced osteogenic differentiation of MSCs on modified Ti surfaces. This hypothesis was tested by culturing human MSCs on tissue culture plastic (TCP), polished (P), micro-rough-hydrophobic (SLA) and micro-...
Subjects
free text keywords: AXL; GAS6; Mesenchymal stromal cells; Adult stem cell; Osteogenesis; Titanium implants
Download from
UCL Discovery
Article . 2014
28 references, page 1 of 2

1. Liu X, Chu P, Ding C (2004) Surface modification of titanium, titanium alloys, and related materials for biomedical applications. Mat Sci Eng 47: 91-121.

2. Wennerberg A, Albrektsson T (2009) Effects of titanium surface topography on bone integration: a systematic review. Clin Oral Impl Res 20: 172-182. [PubMed]

3. Zhao G, Raines A, Wieland M, Schwartz Z, Boyan B (2007) Requirement for both micron and sub-micron scale structure for synergistic responses of osteoblasts to substrate energy and topography. Biomat 31: 2728-2735. [PubMed]

4. Rausch-Fan X, Qu Z, Wieland M, Matejka M, Schedle A (2007) Differentiation and cytokine synthesis of human alveolar osteoblasts compared to osteoblast like cells in response to titanium surfaces. Dent Mater 24: 102-110. [PubMed]

5. Brett P, Harle J, Salih V, Mihoc R, Olsen I, et al. (2004) Roughness response genes in osteoblasts. Bone 35: 124-133. [PubMed]

6. Rupp F, Schneider C, Olshanska N, de Wild M, Wieland M, et al. (2006) Enhancing surface free energy and hydrophilicity through chemical modification of microstructured titanium implant surfaces. J Biomed Mater Res 76: 323-334. [PubMed]

7. Schwartz F, Wieland M, Schwartz Z, Zhao G, Rupp F, et al. (2009) Potential of chemically modified hydrophilic surface characteristics to support tissue integration of titanium dental implants. J Biomedi Mat Res 88: 544-557. [PubMed]

8. Bornstein M, Wittneben J, Bragger U, Buser D (2010) Early loding at 21 days of non-submerged titanium implamts with a chemically modified sandblasted and acid-etched surface: 3-year results of a prospective study in the posterior mandible. J Periodontal 81: 809-818. [PubMed]

9. Schwartz F, Sager M, Kadeka I, Ferrari D, Becker J (2010) Influence of titanium implant surface characteristics on bone regeneration in dehiscence type defects: an experimental study in dogs. J Clin Periodontol 37: 466-473. [PubMed]

10. Lang N, Salvi G, Huynh-Ba G, Ivanovski S, Donos N, et al. (2011) Early osseointegration to hydrophilic and hydrophobic implant surfaces in humans. Clin Oral Impl Res 22: 349-356. [PubMed]

11. Bosshardt D, Salvi G, Huynh-Ba G, Ivanovski S, Donos N, et al. (2011) The role of bone debris in early healing adjacent to hydrophilic and hydrophobic implant surfaces in man. Clin Oral Impl Res 22: 357-364. [PubMed]

12. Donos N, Hamlet S, Lang N, Salvi G, Huynh-Ba G, et al. (2011) Gene expression profile of Gene expression profile of compared with a hydrophobic microrough implant surface. Clin Oral Impl Red 22: 365-372. [PubMed]

13. Ivanovski S, Hamlet S, Salvi G, Huynh-Ba G, Bosshardt D, et al. (2011) Transcriptional profiling of osseointegration in humans. Clin Oral Impl Res 22: 378-381. [PubMed]

14. Ivanovski S, Hamlet S, Retzepi M, Wall I, Donos N (2011) Transcriptional profiling of “guided bone regeneration” in a critical-size calvarial defect. Clin Oral Impl Res 22: 382-389. [PubMed]

15. Wall I, Donos N, Calqvist K, Jones F, Brett P (2009) Modified titanium surfaces promote accelerated osteogenic differentiation of mesenchymal stromal cells in vitro. Bone 45: 17-26. [PubMed]

28 references, page 1 of 2
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