publication . Article . 2019

A comprehensive gene–environment interaction analysis in Ovarian Cancer using genome‐wide significant common variants

Kim, S.; Wang, M.; Tyrer, J. P.; Jensen, A.; Wiensch, A.; Liu, G.; Lee, A. W.; Ness, R. B.; Salvatore, M.; Tworoger, S. S.; ...
Open Access English
  • Published: 01 May 2019
  • Country: United Kingdom
Abstract
As a follow-up to genome-wide association analysis of common variants associated with ovarian carcinoma (cancer), this study considers seven well-known ovarian cancer risk factors and their interactions with 28 genome-wide significant common genetic variants. The interaction analyses were based on data from 9,971 ovarian cancer cases and 15,566 controls from 17 case-control studies. Likelihood ratio and Wald tests for multiplicative interaction and for relative excess risk due to additive interaction were used. The top multiplicative interaction was noted between oral contraceptive pill (OCP) use (ever vs never) and rs13255292 (P-value = 3.48 x 10-4 ). Among wom...
Subjects
free text keywords: G x E, additive interaction, genetics, ovarian cancer
Funded by
NIH| Epidemiology of Ovarian Cancer:New Hypotheses
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01CA087538-02
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| HEREDITARY BREAST CANCER--GENETIC AND MOLECULAR STUDIES
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01CA058860-02
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| Training Grant in Genomic Analysis and Interpretation
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5T32ES013678-05
  • Funding stream: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
,
NIH| Premenopausal Hormone Levels and Risk of Breast Cancer
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01CA067262-08
  • Funding stream: NATIONAL CANCER INSTITUTE
,
NIH| COLLABORATIVE STUDY OF OVARIAN CANCER IN TWO RISK GROUPS
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 5R01CA058598-05
  • Funding stream: NATIONAL CANCER INSTITUTE
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Article . 2019
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