publication . Article . 2020

Amyloid-beta modulates the association between neurofilament light chain and brain atrophy in Alzheimer’s disease

Kang, M. S.; Aliaga, A. A.; Shin, M.; Mathotaarachchi, S.; Benedet, A. L.; Pascoal, T. A.; Therriault, J.; Chamoun, M.; Savard, M.; Devenyi, G. A.; ...
Open Access English
  • Published: 26 Jun 2020
  • Country: United Kingdom
Abstract
Neurofilament light chain (NFL) measurement has been gaining strong support as a clinically useful neuronal injury biomarker for various neurodegenerative conditions. However, in Alzheimer’s disease (AD), its reflection on regional neuronal injury in the context of amyloid pathology remains unclear. This study included 83 cognitively normal (CN), 160 mild cognitive impairment (MCI), and 73 AD subjects who were further classified based on amyloid-beta (Aβ) status as positive or negative (Aβ+ vs Aβ−). In addition, 13 rats (5 wild type and 8 McGill-R-Thy1-APP transgenic (Tg)) were examined. In the clinical study, reduced precuneus/posterior cingulate cortex and hip...
Subjects
Medical Subject Headings: mental disorders
free text keywords: Biomarkers, Diseases, Molecular biology, Neuroscience
Funded by
CIHR
Project
  • Funder: Canadian Institutes of Health Research (CIHR)
,
EC| PATHAD
Project
PATHAD
Pathways to Alzheimer's disease
  • Funder: European Commission (EC)
  • Project Code: 681712
  • Funding stream: H2020 | ERC | ERC-COG
,
NIH| Alzheimers Disease Neuroimaging Initiative
Project
  • Funder: National Institutes of Health (NIH)
  • Project Code: 1U01AG024904-01
  • Funding stream: NATIONAL INSTITUTE ON AGING
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UCL Discovery
Article . 2020
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