Identification of Therapeutic Targets of Inflammatory Monocyte Recruitment to Modulate the Allogeneic Injury to Donor Cornea

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Lapp, T.; Zaher, S. S.; Haas, C. T.; Becker, D. L.; Thrasivoulou, C.; Chain, B. M.; Larkin, D. F. P.; Noursadeghi, M.;
  • Subject: Science & technology, life sciences & biomedicine, ophthalmology, corneal transplantation, ocular immunology, monocytes, chemotaxis, anti-cd4 monoclonal-antibody, controlled clinical-trial, blood-brain-barrier, allograft-rejection, endothelial-cells, rheumatoid-arthritis, gene-expression, aqueous-humor, double-blind, macrophages

Purpose: We sought to test the hypothesis that monocytes contribute to the immunopathogenesis of corneal allograft rejection and identify therapeutic targets to inhibit monocyte recruitment. Methods: Monocytes and proinflammatory mediators within anterior chamber sam... View more
  • References (39)
    39 references, page 1 of 4

    1. Report of the organ transplant panel. Corneal transplantation. Council on Scientific Affairs. JAMA 1988;259:719-722.

    2. Williams KA, Lowe M, Bartlett C, Kelly TL, Coster DJ, All C. Risk factors for human corneal graft failure within the Australian corneal graft registry. Transplantation 2008;86:1720-1724.

    3. Yamada J, Kurimoto I, Streilein JW. Role of CD4+ T cells in immunobiology of orthotopic corneal transplants in mice. Invest Ophthalmol Vis Sci 1999;40:2614-2621.

    4. He YG, Ross J, Niederkorn JY. Promotion of murine orthotopic corneal allograft survival by systemic administration of anti-CD4 monoclonal antibody. Invest Ophthalmol Vis Sci 1991;32:2723-2728.

    5. Ayliffe W, Alam Y, Bell EB, McLeod D, Hutchinson IV. Prolongation of rat corneal graft survival by treatment with anti-CD4 monoclonal antibody. Br J Ophthalmol 1992;76:602-606.

    6. Niederkorn JY, Stevens C, Mellon J, Mayhew E. CD4+ T-cell-independent rejection of corneal allografts.

    Transplantation 2006;81:1171-1178.

    7. Niederkorn JY. Immune mechanisms of corneal allograft rejection. Curr Eye Res 2007;32:1005-1016.

    8. Chatel MA, Larkin DF. Sirolimus and mycophenolate as combination prophylaxis in corneal transplant recipients at high rejection risk. Am J Ophthalmol 2010;150:179-184.

    9. Larkin DF, Calder VL, Lightman SL. Identification and characterization of cells infiltrating the graft and aqueous humour in rat corneal allograft rejection. Clin Exper Immunol 1997;107:381-391.

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