Induced pluripotent stem (iPS) cells from human fetal stem cells
Guillot, P. V.
- Publisher: ELSEVIER SCI LTD
Reprogramming, small molecules, fetal stem cells, induced pluripotency, transcription factors, translational medicine, Mesenchymal Stromal Cells, Small-molecule Compounds, OCT4 Promoter Activity, Valproic Acid, Somatic-cells, Osteogenesis Imperfecta, Human Fibroblasts, Nuclear Transfer, Defined Factors, High-efficiency
Pluripotency defines the ability of stem cells to differentiate into all the lineages of the three germ layers and self-renew indefinitely. Somatic cells can regain the developmental potential of embryonic stem cells following ectopic expression of a set of transcription factors or, in certain circumstances, via modulation of culture conditions and supplementation with small molecule, that is, induced pluripotent stem (iPS) cells. Here, we discuss the use of fetal tissues for reprogramming, focusing in particular on stem cells derived from human amniotic fluid, and the development of chemical reprogramming. We next address the advantages and disadvantages of deriving pluripotent cells from fetal tissues and the potential clinical applications.