Genomic variation in CYP3A4: type, frequencies and potential implications for pharmacogenetic understanding.

Doctoral thesis English OPEN
Creemer, O.;
  • Publisher: UCL (University College London)

The human cytochrome P450 3A subfamily metabolises endogenous substances and approximately half of all currently available drugs. There is marked inter-individual variation in hepatic expression of the major adult isoform, CYP3A4; the genetic component of this variabili... View more
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