publication . Article . 2017

Elevated Striatal Dopamine Function in Immigrants and Their Children: A Risk Mechanism for Psychosis

Egerton, Alice; Howes, Oliver D; Houle, Sylvain; McKenzie, Kwame; Valmaggia, Lucia R; Bagby, Michael R; Tseng, Huai-Hsuan; Bloomfield, Michael A P; Kenk, Miran; Bhattacharyya, Sagnik; ...
Open Access English
  • Published: 01 Mar 2017 Journal: Schizophrenia Bulletin, volume 43, issue 2, pages 293-301 (issn: 0586-7614, eissn: 1745-1701, Copyright policy)
  • Publisher: Oxford University Press
Abstract
Abstract Migration is a major risk factor for schizophrenia but the neurochemical processes involved are unknown. One candidate mechanism is through elevations in striatal dopamine synthesis and release. The objective of this research was to determine whether striatal dopamine function is elevated in immigrants compared to nonimmigrants and the relationship with psychosis. Two complementary case–control studies of in vivo dopamine function (stress-induced dopamine release and dopamine synthesis capacity) in immigrants compared to nonimmigrants were performed in Canada and the United Kingdom. The Canadian dopamine release study included 25 immigrant and 31 nonmig...
Subjects
free text keywords: stress, schizophrenia, stress, positron emission tomography, schizophrenia, positron emission tomography, Invited Themed Article
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publication . Article . 2017

Elevated Striatal Dopamine Function in Immigrants and Their Children: A Risk Mechanism for Psychosis

Egerton, Alice; Howes, Oliver D; Houle, Sylvain; McKenzie, Kwame; Valmaggia, Lucia R; Bagby, Michael R; Tseng, Huai-Hsuan; Bloomfield, Michael A P; Kenk, Miran; Bhattacharyya, Sagnik; ...