A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation

Article English OPEN
Psychosis Endophenotypes International Consortium; Wellcome Trust Case-Control Consortium; Bramon, E.; Pirinen, M.; Strange, A.; Lin, K.; Freeman, C.; Bellenguez, C.; Su, Z.; Band, G.; Pearson, R.; Vukcevic, D.; Langford, C.; Deloukas, P.; Hunt, S.; Gray, E.; Dronov, S.; Potter, S. C.; Tashakkori-Ghanbaria, A.; Edkins, S.; Bumpstead, S. J.; Arranz, M. J.; Bakker, S.; Bender, S.; Bruggeman, R.; Cahn, W.; Chandler, D.; Collier, D. A.; Crespo-Facorro, B.; Dazzan, P.; ... view all 85 authors
(2014)
  • Subject: Bipolar disorder, genome-wide association, meta-analysis, polygenic score analysis, psychosis, schizophrenia

BACKGROUND: Genome-wide association studies (GWAS) have identified several loci associated with schizophrenia and/or bipolar disorder. We performed a GWAS of psychosis as a broad syndrome rather than within specific diagnostic categories. METHODS: 1239 cases with sch... View more
  • References (106)
    106 references, page 1 of 11

    14. Athanasiu L, Mattingsdal M, Kähler AK, Brown A, Gustafsson O, Agartz I, et al. (2010): Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort. Journal of psychiatric research. 44:748-753.

    15. Green EK, Grozeva D, Jones I, Jones L, Kirov G, Caesar S, et al. (2010): The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia. Molecular psychiatry. 15:1016-1022.

    16. Kirov G, Zaharieva I, Georgieva L, Moskvina V, Nikolov I, Cichon S, et al. (2008): A genome-wide association study in 574 schizophrenia trios using DNA pooling. Molecular psychiatry. 14:796-803.

    17. Need AC, Ge D, Weale ME, Maia J, Feng S, Heinzen EL, et al. (2009): A GenomeWide Investigation of SNPs and CNVs in Schizophrenia. PLoS Genet. 5:e1000373.

    18. O'Donovan MC, Craddock N, Norton N, Williams H, Peirce T, Moskvina V, et al. (2008): Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat Genet. 40:1053-1055.

    19. O'Donovan MC, Norton N, Williams H, Peirce T, Moskvina V, Nikolov I, et al. (2009): Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2. Molecular psychiatry. 14:30-36.

    20. Sachdev P, Smith JS, Cathcart S (2001): Schizophrenia-like psychosis following traumatic brain injury: a chart-based descriptive and case-control study. Psychological medicine. 31:231-239.

    21. Shi Y, Li Z, Xu Q, Wang T, Li T, Shen J, et al. (2011): Common variants on 8p12 and 1q24.2 confer risk of schizophrenia. Nat Genet. 43:1224-1227.

    22. Shifman S, Johannesson M, Bronstein M, Chen SX, Collier DA, Craddock NJ, et al. (2008): Genome-Wide Association Identifies a Common Variant in the Reelin Gene That Increases the Risk of Schizophrenia Only in Women. PLoS Genet. 4:e28.

    23. Shi J, Levinson DF, Duan J, Sanders AR, Zheng Y, Pe'er I, et al. (2009): Common variants on chromosome 6p22.1 are associated with schizophrenia. Nature. 460:753-757.

  • Related Research Results (4)
  • Metrics