A genome-wide association analysis of a broad psychosis phenotype identifies three loci for further investigation

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Psychosis Endophenotypes International Consortium; Wellcome Trust Case-Control Consortium; Bramon, E.; Pirinen, M.; Strange, A.; Lin, K.; Freeman, C.; Bellenguez, C.; Su, Z.; Band, G.; Pearson, R.; Vukcevic, D.; Langford, C.; Deloukas, P.; Hunt, S.; Gray, E.; Dronov, S.; Potter, S. C.; Tashakkori-Ghanbaria, A.; Edkins, S.; Bumpstead, S. J.; Arranz, M. J.; Bakker, S.; Bender, S.; Bruggeman, R.; Cahn, W.; Chandler, D.; Collier, D. A.; Crespo-Facorro, B.; Dazzan, P.; ... view all 85 authors
  • Subject: Bipolar disorder, genome-wide association, meta-analysis, polygenic score analysis, psychosis, schizophrenia

BACKGROUND: Genome-wide association studies (GWAS) have identified several loci associated with schizophrenia and/or bipolar disorder. We performed a GWAS of psychosis as a broad syndrome rather than within specific diagnostic categories. METHODS: 1239 cases with sch... View more
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