Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a

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Deuis, J. R. ; Dekan, Z. ; Wingerd, J. S. ; Smith, J. J. ; Munasinghe, N. R. ; Bhola, R. F. ; Imlach, W. L. ; Herzig, V. ; Armstrong, D. A. ; Rosengren, K. J. ; Bosmans, F. ; Waxman, S. G. ; Dib-Hajj, S. D. ; Escoubas, P. ; Minett, M. S. ; Christie, M. J. ; King, G. F. ; Alewood, P. F. ; Lewis, R. J. ; Wood, J. N. ; Vetter, I. (2017)
  • Publisher: Nature Publishing Group
  • Journal: Scientific Reports, volume 7 (issn: 2045-2322, eissn: 2045-2322)
  • Related identifiers: doi: 10.1038/srep40883, pmc: PMC5247677
  • Subject: Article

Human genetic studies have implicated the voltage-gated sodium channel NaV1.7 as a therapeutic target for the treatment of pain. A novel peptide, μ-theraphotoxin-Pn3a, isolated from venom of the tarantula Pamphobeteus nigricolor, potently inhibits NaV1.7 (IC50 0.9 nM) w... View more
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