Low α-defensin gene copy number increases the risk for IgA nephropathy and renal dysfunction

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Ai, Z.; Li, M.; Liu, W.; Foo, J. N.; Mansouri, O.; Yin, P.; Zhou, Q.; Tang, X.; Dong, X.; Feng, S.; Xu, R.; Zhong, Z.; Chen, J.; Wan, J.; Lou, T.; Yu, J.; Zhou, Q.; Fan, J.; Mao, H.; Gale, D.; Barratt, J.; Armour, J. A.; Liu, J.; Yu, X.;

Although a major source of genetic variation, copy number variations (CNVs) and their involvement in disease development have not been well studied. Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. We performed association ana... View more
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