publication . Article . Other literature type . 2016

Adversity in childhood linked to elevated striatal dopamine function in adulthood.

Egerton A; Lr, Valmaggia; Od, Howes; Day F; Ca, Chaddock; Allen P; Tt, Winton-Brown; Michael Bloomfield; Bhattacharyya S; Chilcott J; ...
Open Access English
  • Published: 01 Oct 2016 Journal: Schizophrenia Research, issue 2-3, pages 171-176 (issn: 09209964, Copyright policy)
  • Publisher: The Authors. Published by Elsevier B.V.
  • Country: United Kingdom
Abstract
Childhood adversity increases the risk of psychosis in adulthood. Theoretical and animal models suggest that this effect may be mediated by increased striatal dopamine neurotransmission. The primary objective of this study was to examine the relationship between adversity in childhood and striatal dopamine function in early adulthood. Secondary objectives were to compare exposure to childhood adversity and striatal dopamine function in young people at ultra high risk (UHR) of psychosis and healthy volunteers. Sixty-seven young adults, comprising 47 individuals at UHR for psychosis and 20 healthy volunteers were recruited from the same geographic area and were ma...
Subjects
free text keywords: Dopamine, Psychosis, Childhood adversity, PET, At risk mental state, social defeat, Article, 11 Medical And Health Sciences, 17 Psychology And Cognitive Sciences, Biological Psychiatry, Psychiatry and Mental health, medicine.disease, medicine, Clinical psychology, Geographic area, Sexual abuse, Striatum, Psychiatry, medicine.medical_specialty, medicine.drug, Psychology, Developmental psychology, Young adult
41 references, page 1 of 3

Antelman, S.M., Eichler, A.J., Black, C.A., Kocan, D.. Interchangeability of stress and amphetamine in sensitization. Science. 1980; 207 (4428): 329-331 [OpenAIRE] [PubMed]

Bifulco, A., Bernazzani, O., Moran, P.M., Jacobs, C.. The childhood experience of care and abuse questionnaire (CECA.Q): validation in a community series. Br. J. Clin. Psychol.. 2005; 44 (Pt 4): 563-581 [PubMed]

Binbay, T., Drukker, M., Elbi, H., Tanik, F.A., Ozkinay, F., Onay, H., Zagli, N., van Os, J., Alptekin, K.. Testing the psychosis continuum: differential impact of genetic and nongenetic risk factors and comorbid psychopathology across the entire spectrum of psychosis. Schizophr. Bull.. 2012; 38 (5): 992-1002 [OpenAIRE] [PubMed]

Casanueva, C., Dozier, M., Tueller, S., Dolan, M., Smith, K., Webb, M.B., Westbrook, T., Harden, B.J.. Caregiver instability and early life changes among infants reported to the child welfare system. Child Abuse Negl.. 2014; 38 (3): 498-509 [OpenAIRE] [PubMed]

Egerton, A., Chaddock, C.A., Winton-Brown, T.T., Bloomfield, M.A., Bhattacharyya, S., Allen, P., McGuire, P.K., Howes, O.D.. Presynaptic striatal dopamine dysfunction in people at ultra-high risk for psychosis: findings in a second cohort. Biol. Psychiatry. 2013; 74 (2): 106-112 [PubMed]

Fisher, H.L., Craig, T.K., Fearon, P., Morgan, K., Dazzan, P., Lappin, J., Hutchinson, G., Doody, G.A., Jones, P.B., McGuffin, P., Murray, R.M., Leff, J., Morgan, C.. Reliability and comparability of psychosis patients' retrospective reports of childhood abuse. Schizophr. Bull.. 2011; 37 (3): 546-553 [OpenAIRE] [PubMed]

Frissa, S., Hatch, S.L., Gazard, B., team, S.E.s., Fear, N.T., Hotopf, M.. Trauma and current symptoms of PTSD in a South East London community. Soc. Psychiatry Psychiatr. Epidemiol.. 2013; 48 (8): 1199-1209 [OpenAIRE] [PubMed]

Gevonden, M., Booij, J., van den Brink, W., Heijtel, D., van Os, J., Selten, J.P.. Increased release of dopamine in the striata of young adults with hearing impairment and its relevance for the social defeat hypothesis of schizophrenia. JAMA Psychiatry. 2014 [OpenAIRE]

Hamilton, M.. The assessment of anxiety states by rating. Br. J. Med. Psychol.. 1959; 32 (1): 50-55 [PubMed]

Hamilton, M.. A rating scale for depression. J. Neurol. Neurosurg. Psychiatry. 1960; 23: 56-62 [OpenAIRE] [PubMed]

Hammers, A., Allom, R., Koepp, M.J., Free, S.L., Myers, R., Lemieux, L., Mitchell, T.N., Brooks, D.J., Duncan, J.S.. Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe. Hum. Brain Mapp.. 2003; 19 (4): 224-247 [OpenAIRE] [PubMed]

Howes, O.D., Kapur, S.. The dopamine hypothesis of schizophrenia: version III–the final common pathway. Schizophr. Bull.. 2009; 35 (3): 549-562 [OpenAIRE] [PubMed]

Howes, O.D., McDonald, C., Cannon, M., Arseneault, L., Boydell, J., Murray, R.M.. Pathways to schizophrenia: the impact of environmental factors. Int. J. Neuropsychopharmacol.. 2004; 7 (Suppl. 1): S7-S13 [PubMed]

Howes, O.D., Montgomery, A.J., Asselin, M.C., Murray, R.M., Valli, I., Tabraham, P., Bramon-Bosch, E., Valmaggia, L., Johns, L., Broome, M., McGuire, P.K., Grasby, P.M.. Elevated striatal dopamine function linked to prodromal signs of schizophrenia. Arch. Gen. Psychiatry. 2009; 66 (1): 13-20 [PubMed]

Howes, O., Bose, S., Turkheimer, F., Valli, I., Egerton, A., Stahl, D., Valmaggia, L., Allen, P., Murray, R., McGuire, P.. Progressive increase in striatal dopamine synthesis capacity as patients develop psychosis: a PET study. Mol. Psychiatry. 2011: 885-886 [OpenAIRE] [PubMed]

41 references, page 1 of 3
Abstract
Childhood adversity increases the risk of psychosis in adulthood. Theoretical and animal models suggest that this effect may be mediated by increased striatal dopamine neurotransmission. The primary objective of this study was to examine the relationship between adversity in childhood and striatal dopamine function in early adulthood. Secondary objectives were to compare exposure to childhood adversity and striatal dopamine function in young people at ultra high risk (UHR) of psychosis and healthy volunteers. Sixty-seven young adults, comprising 47 individuals at UHR for psychosis and 20 healthy volunteers were recruited from the same geographic area and were ma...
Subjects
free text keywords: Dopamine, Psychosis, Childhood adversity, PET, At risk mental state, social defeat, Article, 11 Medical And Health Sciences, 17 Psychology And Cognitive Sciences, Biological Psychiatry, Psychiatry and Mental health, medicine.disease, medicine, Clinical psychology, Geographic area, Sexual abuse, Striatum, Psychiatry, medicine.medical_specialty, medicine.drug, Psychology, Developmental psychology, Young adult
41 references, page 1 of 3

Antelman, S.M., Eichler, A.J., Black, C.A., Kocan, D.. Interchangeability of stress and amphetamine in sensitization. Science. 1980; 207 (4428): 329-331 [OpenAIRE] [PubMed]

Bifulco, A., Bernazzani, O., Moran, P.M., Jacobs, C.. The childhood experience of care and abuse questionnaire (CECA.Q): validation in a community series. Br. J. Clin. Psychol.. 2005; 44 (Pt 4): 563-581 [PubMed]

Binbay, T., Drukker, M., Elbi, H., Tanik, F.A., Ozkinay, F., Onay, H., Zagli, N., van Os, J., Alptekin, K.. Testing the psychosis continuum: differential impact of genetic and nongenetic risk factors and comorbid psychopathology across the entire spectrum of psychosis. Schizophr. Bull.. 2012; 38 (5): 992-1002 [OpenAIRE] [PubMed]

Casanueva, C., Dozier, M., Tueller, S., Dolan, M., Smith, K., Webb, M.B., Westbrook, T., Harden, B.J.. Caregiver instability and early life changes among infants reported to the child welfare system. Child Abuse Negl.. 2014; 38 (3): 498-509 [OpenAIRE] [PubMed]

Egerton, A., Chaddock, C.A., Winton-Brown, T.T., Bloomfield, M.A., Bhattacharyya, S., Allen, P., McGuire, P.K., Howes, O.D.. Presynaptic striatal dopamine dysfunction in people at ultra-high risk for psychosis: findings in a second cohort. Biol. Psychiatry. 2013; 74 (2): 106-112 [PubMed]

Fisher, H.L., Craig, T.K., Fearon, P., Morgan, K., Dazzan, P., Lappin, J., Hutchinson, G., Doody, G.A., Jones, P.B., McGuffin, P., Murray, R.M., Leff, J., Morgan, C.. Reliability and comparability of psychosis patients' retrospective reports of childhood abuse. Schizophr. Bull.. 2011; 37 (3): 546-553 [OpenAIRE] [PubMed]

Frissa, S., Hatch, S.L., Gazard, B., team, S.E.s., Fear, N.T., Hotopf, M.. Trauma and current symptoms of PTSD in a South East London community. Soc. Psychiatry Psychiatr. Epidemiol.. 2013; 48 (8): 1199-1209 [OpenAIRE] [PubMed]

Gevonden, M., Booij, J., van den Brink, W., Heijtel, D., van Os, J., Selten, J.P.. Increased release of dopamine in the striata of young adults with hearing impairment and its relevance for the social defeat hypothesis of schizophrenia. JAMA Psychiatry. 2014 [OpenAIRE]

Hamilton, M.. The assessment of anxiety states by rating. Br. J. Med. Psychol.. 1959; 32 (1): 50-55 [PubMed]

Hamilton, M.. A rating scale for depression. J. Neurol. Neurosurg. Psychiatry. 1960; 23: 56-62 [OpenAIRE] [PubMed]

Hammers, A., Allom, R., Koepp, M.J., Free, S.L., Myers, R., Lemieux, L., Mitchell, T.N., Brooks, D.J., Duncan, J.S.. Three-dimensional maximum probability atlas of the human brain, with particular reference to the temporal lobe. Hum. Brain Mapp.. 2003; 19 (4): 224-247 [OpenAIRE] [PubMed]

Howes, O.D., Kapur, S.. The dopamine hypothesis of schizophrenia: version III–the final common pathway. Schizophr. Bull.. 2009; 35 (3): 549-562 [OpenAIRE] [PubMed]

Howes, O.D., McDonald, C., Cannon, M., Arseneault, L., Boydell, J., Murray, R.M.. Pathways to schizophrenia: the impact of environmental factors. Int. J. Neuropsychopharmacol.. 2004; 7 (Suppl. 1): S7-S13 [PubMed]

Howes, O.D., Montgomery, A.J., Asselin, M.C., Murray, R.M., Valli, I., Tabraham, P., Bramon-Bosch, E., Valmaggia, L., Johns, L., Broome, M., McGuire, P.K., Grasby, P.M.. Elevated striatal dopamine function linked to prodromal signs of schizophrenia. Arch. Gen. Psychiatry. 2009; 66 (1): 13-20 [PubMed]

Howes, O., Bose, S., Turkheimer, F., Valli, I., Egerton, A., Stahl, D., Valmaggia, L., Allen, P., Murray, R., McGuire, P.. Progressive increase in striatal dopamine synthesis capacity as patients develop psychosis: a PET study. Mol. Psychiatry. 2011: 885-886 [OpenAIRE] [PubMed]

41 references, page 1 of 3
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . Other literature type . 2016

Adversity in childhood linked to elevated striatal dopamine function in adulthood.

Egerton A; Lr, Valmaggia; Od, Howes; Day F; Ca, Chaddock; Allen P; Tt, Winton-Brown; Michael Bloomfield; Bhattacharyya S; Chilcott J; ...