Adversity in childhood linked to elevated striatal dopamine function in adulthood

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Egerton, A.; Valmaggia, L. R.; Howes, O. D.; Day, F.; Chaddock, C. A.; Allen, P.; Winton-Brown, T. T.; Bloomfield, M. A. P.; Bhattacharyya, S.; Chilcott, J.; Lappin, J. M.; Murray, R. M.; McGuire, P.;
  • Publisher: Elsevier Science Publisher B. V
  • Journal: Schizophrenia Research,volume 176,issue 2-3,pages171-176 (issn: 0920-9964, eissn: 1573-2509)
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  • Related identifiers: pmc: PMC5147458, doi: 10.1016/j.schres.2016.06.005
  • Subject: Biological Psychiatry | 17 Psychology And Cognitive Sciences | At risk mental state | 11 Medical And Health Sciences | Psychiatry | Childhood adversity | Dopamine | social defeat | PET | Psychosis | Article | Psychiatry and Mental health

Childhood adversity increases the risk of psychosis in adulthood. Theoretical and animal models suggest that this effect may be mediated by increased striatal dopamine neurotransmission. The primary objective of this study was to examine the relationship between adversi... View more
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