publication . Article . 2016

The physiological role of the brain GLP-1 system in stress

Marie K. Holt; Stefan Trapp;
Open Access English
  • Published: 01 Sep 2016
  • Country: United Kingdom
Abstract Glucagon-like peptide-1 (GLP-1) within the brain is a potent regulator of food intake and most studies have investigated the anorexic effects of central GLP-1. A range of brain regions have now been found to be involved in GLP-1 mediated anorexia, including some which are not traditionally associated with appetite regulation. However, a change in food intake can be indicative of not only reduced energy demand, but also changes in the organism’s motivation to eat following stressful stimuli. In fact, acute stress is well-known to reduce food intake. Recently, more research has focused on the role of GLP-1 in stress and the central GLP-1 system has been f...
Medical Subject Headings: digestive, oral, and skin physiologyendocrine systemhormones, hormone substitutes, and hormone antagonists
free text keywords: Food intake, glucagon-like peptide-1, hypothalamus-pituitary-adrenal axis, preproglucagon neurons, stress, sympathetic nervous system, glucagon-like peptide-1, preproglucagon neurons, stress, food intake, hypothalamus-pituitary-adrenal axis, sympathetic nervous system, Biology (General), QH301-705.5, Review Article, Cardiovascular, Endocrinology, medicine.medical_specialty, medicine, medicine.anatomical_structure, Brainstem, Psychology, Neuroscience, Internal medicine, Anorexia, medicine.symptom, Energy demand, Regulator, Stimulus (physiology), Spinal cord
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publication . Article . 2016

The physiological role of the brain GLP-1 system in stress

Marie K. Holt; Stefan Trapp;