publication . Article . 2016

The physiological role of the brain GLP-1 system in stress

Marie K. Holt; Stefan Trapp;
Open Access English
  • Published: 01 Sep 2016 Journal: Cogent Biology, volume 2, issue 1 (issn: 2331-2025, eissn: 2331-2025, Copyright policy)
  • Publisher: Cogent
Abstract Glucagon-like peptide-1 (GLP-1) within the brain is a potent regulator of food intake and most studies have investigated the anorexic effects of central GLP-1. A range of brain regions have now been found to be involved in GLP-1 mediated anorexia, including some which are not traditionally associated with appetite regulation. However, a change in food intake can be indicative of not only reduced energy demand, but also changes in the organism’s motivation to eat following stressful stimuli. In fact, acute stress is well-known to reduce food intake. Recently, more research has focused on the role of GLP-1 in stress and the central GLP-1 system has been f...
mesheuropmc: endocrine systemhormones, hormone substitutes, and hormone antagonistsdigestive, oral, and skin physiology
free text keywords: stress, hypothalamus-pituitary-adrenal axis, Review Article, sympathetic nervous system, Neuroscience, glucagon-like peptide-1, Food intake, glucagon-like peptide-1, hypothalamus-pituitary-adrenal axis, preproglucagon neurons, stress, sympathetic nervous system, Cardiovascular, QH301-705.5, preproglucagon neurons, Biology (General), food intake, Endocrinology
154 references, page 1 of 11

Anesten, F., Holt, M. K., Schéle, E., Pálsdóttir, V., Reimann, F., Gribble, F. M., … Jansson, J. O. (2016). Preproglucagon neurons in the hindbrain have IL-6 receptor-α and show Ca 2+ inuflx in response to IL-6. American Journal of Physiology - Regulatory, Integrative and Comparative Physiology, 311, R115-R123.

Barrera, J. G., Jones, K. R., Herman, J. P., D'Alessio, D. A., Woods, S. C., & Seeley, R. J. (2011). Hyperphagia and increased fat accumulation in two models of chronic cns glucagon-like peptide-1 loss of function. Journal of Neuroscience, 31, 3904- 3913.

Cork, S. C., Richards, J. E., Holt, M. K., Gribble, F. M., Reimann, F., & Trapp, S. (2015). Distribution and characterisation of glucagon-like peptide-1 receptor expressing cells in the mouse brain. Molecular Metabolism, 4, 718-731. [OpenAIRE]

Dampney, R. A. (1994). Functional organization of central pathways regulating the cardiovascular system.

Physiological Reviews, 74, 323-364.

Dayas, C. V., Buller, K. M., Crane, J. W., Xu, Y., & Day, T. A. (2001).

European Journal of Neuroscience, 14, 1143-1152.

Deacon, C. F. (2004). Circulation and degradation of GIP and GLP-1. Hormone and Metabolic Research, 36, 761-765.

de Heer, J., Rasmussen, C., Coy, D. H., & Holst, J. J. (2008).

Glucagon-like peptide-1, but not glucose-dependent insulinotropic peptide, inhibits glucagon secretion via somatostatin (receptor subtype 2) in the perfused rat pancreas. Diabetologia, 51, 2263-2270.

154 references, page 1 of 11
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 2016

The physiological role of the brain GLP-1 system in stress

Marie K. Holt; Stefan Trapp;