publication . Article . 2016

The physiological role of the brain GLP-1 system in stress

Marie K. Holt; Stefan Trapp;
Open Access English
  • Published: 01 Sep 2016 Journal: Cogent Biology, volume 2, issue 1 (issn: 2331-2025, eissn: 2331-2025, Copyright policy)
  • Publisher: Cogent
Abstract
Abstract Glucagon-like peptide-1 (GLP-1) within the brain is a potent regulator of food intake and most studies have investigated the anorexic effects of central GLP-1. A range of brain regions have now been found to be involved in GLP-1 mediated anorexia, including some which are not traditionally associated with appetite regulation. However, a change in food intake can be indicative of not only reduced energy demand, but also changes in the organism’s motivation to eat following stressful stimuli. In fact, acute stress is well-known to reduce food intake. Recently, more research has focused on the role of GLP-1 in stress and the central GLP-1 system has been f...
Subjects
mesheuropmc: endocrine systemhormones, hormone substitutes, and hormone antagonistsdigestive, oral, and skin physiology
free text keywords: stress, hypothalamus-pituitary-adrenal axis, Review Article, sympathetic nervous system, Neuroscience, glucagon-like peptide-1, Food intake, glucagon-like peptide-1, hypothalamus-pituitary-adrenal axis, preproglucagon neurons, stress, sympathetic nervous system, Cardiovascular, QH301-705.5, preproglucagon neurons, Biology (General), food intake, Endocrinology
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publication . Article . 2016

The physiological role of the brain GLP-1 system in stress

Marie K. Holt; Stefan Trapp;