publication . Thesis . 2016

An investigation into UV-curable gel formulations for topical nail medicines

Kerai, L. V.;
Open Access English
  • Published: 28 Dec 2016
  • Publisher: UCL (University College London)
  • Country: United Kingdom
UV gels are nail cosmetics which are applied on the nail plate surface and polymerised by placing the nail under a UVA nail lamp. The polymeric film formed can reside on the nail plate for up to 3 weeks without developing any visible defects. Using such a formulation as a drug carrier for the treatment of nail diseases, e.g. fungal infections, could address current issues with topical formulations, such as the failure to maintain a drug depot at the desired site and the need for frequent applications. The aim of this thesis was thus to formulate pharmaceutical UV-curable gels, using antifungals as test drugs, and characterise the resulting film’s properties, suc...
Medical Subject Headings: integumentary systemskin and connective tissue diseases
Related Organizations
Download from
UCL Discovery
Thesis . 2016
44 references, page 1 of 3

Achten, G., Andre, J. and Laporte, M. (1991) 'Nails in Light and Electron Microscopy.', Seminars in Dermatology, 10(1), pp. 54-64.

Ahn, T., Lee, J.-P., Kim, J., Oh, S., Chun, M.-K. and Choi, H.-K. (2013) 'Effect of Pressure Sensitive Adhesive and Vehicles on Permeation of Terbinafine Across Porcine Hoof Membrane', Archives of Pharmaceutical Research, 36(11), pp. 1403-1409. [OpenAIRE]

Alshuiref, A., Ibrahim, H., Abduallah, A. and Edali, M. (2013) 'Thermal and Mechanical Analysis of Urethane Acrylate Graft Copolymer Part A: Urethane Macromonomer Base on TDI and EG', International Journal of Chemistry, 5(1), pp. 58-79.

Ameen, M., Lear, J. T., Madan, V., Mohd Mustapa, M. F. and Richardson, M. (2014) 'British Association of Dermatologists' Guidelines for the Management of Onychomycosis 2014', British Journal of Dermatology, 171(5), pp. 937-958. [OpenAIRE]

Andre, J., Scheers, C. and Baran, R. (2014) Normal Nail and Use of Nail Cosmetics and Treatments. Handbook of Cosmetic Science and Technology Fourth edn. Boca Raton, Florida: CRC Press. Taylor & Francis Group., p. 597-608.

Arca, E., Taştan, H. B., Akar, A., Kurumlu, Z. and Gür, A. R. (2002) 'An Open, Randomized, Comparative Study of Oral Fluconazole, Itraconazole and Terbinafine Therapy in Onychomycosis', The Journal of dermatological treatment, 13(1), pp. 3-9. [OpenAIRE]

ASTM-D870 (2015) Standard Practice for Testing Water Resistance of Coatings Using Water Immersion: Available at: (Accessed: 2 June 2016).

Avner, S., Nir, N. and Henri, T. (2005) 'Combination of Oral Terbinafine and Topical Ciclopirox Compared to Oral Terbinafine for the Treatment of Onychomycosis', The Journal of Dermatological Treatment, 16(5-6), pp. 327-330.

Badali, H., Mohammadi, R., Mashedi, O., Hoog, G. S. and Meis, J. F. (2015) 'In Vitro Susceptibility Patterns of Clinically Important Trichophyton and Epidermophyton Species Against Nine Antifungal Drugs', Mycoses, 58(5), pp. 303-307. [OpenAIRE]

Baden, H. P. (1994) 'Treatment of Distal Onychomycosis with Avulsion and Topical Antifungal Agents under Occlusion', Arch Dermatol, 130(5), pp. 558-9. [OpenAIRE]

Baden, H. P., Goldsmith, L. A. and Fleming, B. (1973) 'A Comparative Study of the Physicochemical Properties of Human Keratinised Tissues.', Biochimica et Biophysica Acta, 322, pp. 269-278.

Baran, R. (2010) 'The Burden of Nail Psoriasis: An Introduction', Dermatology, 221, pp. 1-5.

Baran, R., Feuilhade, M., Datry, A., Goettmann, S., Pietrini, P., Viguie, C., Badillet, G., Larnier, C. and Czernielewski, J. (2000) 'A Randomized Trial of Amorolfine 5% Solution Nail Lacquer Combined with Oral Terbinafine Compared with Terbinafine Alone in the Treatment of Dermatophytic Toenail Onychomycoses Affecting the Matrix Region', British Journal of Dermatology, 142(6), pp. 1177-1183.

Baran, R., Hay, R. J. and Garduno, J. I. (2008a) 'Review of Antifungal Therapy and the Severity Index for Assessing Onychomycosis: Part I', The Journal of Dermatological Treatment, 19(2), pp. 72-81.

Baran, R., Hay, R. J. and Garduno, J. I. (2008b) 'Review of Antifungal Therapy, Part II: Treatment Rationale, including Specific Patient Populations', The Journal of Dermatological Treatment, 19(3), pp. 168- 75.

44 references, page 1 of 3
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue