publication . Article . 2008

Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome

Mehdi Yeganeh; Philipp Henneke; Nima Rezaei; Stephan Ehl; Doerte Thiel; Núria Matamoros; Cristina Pietrogrande; Teresa Espanol; Jiri Litzman; José Luis Franco; ...
Open Access English
  • Published: 01 Jan 2008
  • Publisher: Ludwig-Maximilians-Universität München
  • Country: Germany
Abstract
Hyper IgE syndromes (HIES) are primary immunodeficiency disorders of unknown pathogenesis. Patients are typically affected with `cold' abscesses of the skin, recurrent cyst-forming pneumonia, chronic mucocutaneous candidiasis and other less frequent features such as progressive skeletal abnormalities. Defective signaling in the Toll-like receptor (TLR) pathways has been suggested as a responsible pathologic mechanism, however, in previous reports, 10 patients revealed no defect in inflammatory cytokine responses to different TLR ligands. Here, we report the increase in pro-inflammatory cytokines TNF-alpha and IL-8, following TLR2 and TLR4 stimulation in a larger...
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free text keywords: Medizin, Immunology, Immunology and Allergy, General Medicine, ddc:610, Peripheral blood mononuclear cell, Primary immunodeficiency, medicine.disease, medicine, Toll-like receptor, business.industry, business, Blood cell, medicine.anatomical_structure, Cytokine, medicine.medical_treatment, Tumor necrosis factor alpha, Endocrinology, medicine.medical_specialty, Pathogenesis, Internal medicine, Immunoglobulin E, biology.protein, biology
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