publication . Article . 2008

Toll-Like Receptor Stimulation Induces Higher TNF-α Secretion in Peripheral Blood Mononuclear Cells from Patients with Hyper IgE Syndrome

Yeganeh, Mehdi; Henneke, Philipp; Rezaei, Nima; Ehl, Stephan; Thiel, Doerte; Matamoros, Nuria; Pietrogrande, Cristina; Espanol, Teresa; Litzman, Jiri; Franco, Jose L.; ...
Open Access
  • Published: 01 Jan 2008 Journal: International Archives of Allergy and Immunology, volume 146, pages 190-194 (issn: 1018-2438, eissn: 1423-0097, Copyright policy)
  • Publisher: S. Karger AG
  • Country: Germany
Abstract
Hyper IgE syndromes (HIES) are primary immunodeficiency disorders of unknown pathogenesis. Patients are typically affected with `cold' abscesses of the skin, recurrent cyst-forming pneumonia, chronic mucocutaneous candidiasis and other less frequent features such as progressive skeletal abnormalities. Defective signaling in the Toll-like receptor (TLR) pathways has been suggested as a responsible pathologic mechanism, however, in previous reports, 10 patients revealed no defect in inflammatory cytokine responses to different TLR ligands. Here, we report the increase in pro-inflammatory cytokines TNF-alpha and IL-8, following TLR2 and TLR4 stimulation in a larger...
Subjects
free text keywords: Medizin, Immunology, Immunology and Allergy, General Medicine, Internal medicine, medicine.medical_specialty, medicine, Peripheral blood mononuclear cell, Cytokine, medicine.medical_treatment, Toll-like receptor, Primary immunodeficiency, medicine.disease, Blood cell, medicine.anatomical_structure, Pathogenesis, Endocrinology, Immunoglobulin E, biology.protein, biology, business.industry, business, Tumor necrosis factor alpha, ddc:610
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publication . Article . 2008

Toll-Like Receptor Stimulation Induces Higher TNF-α Secretion in Peripheral Blood Mononuclear Cells from Patients with Hyper IgE Syndrome

Yeganeh, Mehdi; Henneke, Philipp; Rezaei, Nima; Ehl, Stephan; Thiel, Doerte; Matamoros, Nuria; Pietrogrande, Cristina; Espanol, Teresa; Litzman, Jiri; Franco, Jose L.; ...