Cholesterol biosynthesis is a major target for the controlling and manipulation of biochemical processes in mammals, and thus essential for the development of therapeutic drugs. Diseases associated with a malfunctioning cholesterol biosynthesis include hypercholesteremia, Alzheimer- and Creutzfeld-Jacob disease, to name but a few. Within the scope of this thesis, new amine-substituted spiroacetals from Grundmanns Keton and alpha-Tetralone were developed. Additionally, several compounds could be identified as specific inhibitors of human delta8,7-Sterolisomerase.
free text keywords: Fakultät für Chemie und Pharmazie, ddc:500, ddc:540