publication . Doctoral thesis . 2011

Amin-substituierte Spiroacetale von Grundmanns Keton als neuartige Inhibitoren der humanen ∆8,7-Sterolisomerase

Krojer, Melanie;
Open Access
  • Published: 18 Jul 2011
  • Publisher: Ludwig-Maximilians-Universität München
  • Country: Germany
Abstract
Cholesterol biosynthesis is a major target for the controlling and manipulation of biochemical processes in mammals, and thus essential for the development of therapeutic drugs. Diseases associated with a malfunctioning cholesterol biosynthesis include hypercholesteremia, Alzheimer- and Creutzfeld-Jacob disease, to name but a few. Within the scope of this thesis, new amine-substituted spiroacetals from Grundmanns Keton and alpha-Tetralone were developed. Additionally, several compounds could be identified as specific inhibitors of human delta8,7-Sterolisomerase.
Subjects
free text keywords: Fakultät für Chemie und Pharmazie, ddc:500, ddc:540
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